research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
The study explores the synthesis of functionalized thiohydrazides for creating heterocyclic derivatives of steroids, which are significant in drug discovery due to their biological activity, particularly as anticancer agents for breast and prostate cancers. The research outlines a flexible synthetic approach to produce various steroid derivatives, including pyrazolines, thiadiazoles, thiadiazines, and pyridazines, with controlled heterocyclization patterns. The synthesized compounds demonstrated antiproliferative activity against cancer cell lines, with some lead compounds showing potent selectivity and significant effects on signaling pathways, even in tamoxifen-resistant cells.
