Local Stimulation of Sebaceous Gland Activity by the Topical Administration of Dehydroepiandrosterone

Topical dehydroepiandrosterone (DHEA) at 1% concentration significantly increased sebaceous gland activity in female Syrian hamsters by 80% after two weeks without systemic effects. Effective at concentrations as low as 0.1%, DHEA showed no systemic side effects even at higher doses. In women, DHEA doubled sebum production over 1.5 years without adverse effects, proving it safe and effective for stimulating sebum production, particularly beneficial for post-menopausal women with reduced sebum output.