TLDR Hypothyroidism harms rat skin, but topical triiodothyronine may help improve it.
The study from 2015 investigated the impact of hypothyroidism on the skin of adult male albino rats and the potential therapeutic effects of topical triiodothyronine (T3). It involved 24 rats divided into a control group, two hypothyroid groups for 12 and 16 weeks, and a hypothyroid group treated with topical T3. The hypothyroid rats showed significant skin changes, including thinner epidermis, disorganized hair follicles, decreased cell proliferation, and reduced collagen fibers. Treatment with topical T3 led to improvements in skin histology, suggesting that T3 can reverse the adverse effects of hypothyroidism on the skin. The study concluded that hypothyroidism detrimentally affects skin structure and function, but topical T3 may serve as an effective therapy. Specific numbers regarding the improvement were not provided in the summary.
28 citations,
January 2013 in “Journal of Thyroid Research” Thyroid hormone may speed up wound healing and hair growth, but more research is needed to understand its role in skin repair and use as a treatment.
44 citations,
July 2011 in “Dermato-endocrinology” Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.
49 citations,
December 2009 in “Journal of Investigative Dermatology” Thyroid function affects skin health, with a complex interaction between the two.
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
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April 2000 in “British journal of dermatology/British journal of dermatology, Supplement” Thyroid hormone receptor β1 is found in human hair follicles and helps them survive.
21 citations,
January 2020 in “General and Comparative Endocrinology” Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
6 citations,
January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” Gray hair regained color after thyroid hormone treatment.
28 citations,
January 2013 in “Journal of Thyroid Research” Thyroid hormone may speed up wound healing and hair growth, but more research is needed to understand its role in skin repair and use as a treatment.
32 citations,
March 2021 in “Journal of endocrinological investigation” Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.
Thyroid problems can cause hair loss and change hair texture.
