This review explores the mechanisms and clinical applications of thymosin β4, highlighting its potential in various medical fields, but it presents no new research findings.
October 2025 in “Science Advances” In this study, researchers demonstrated that CD4 T cells from skin-draining lymph nodes in mice with alopecia areata can transfer the disease to recipient mice, revealing a critical role for CD4 T cells in disease development and suggesting potential therapeutic targets.
47 citations
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July 1997 in “British Journal of Dermatology” This research observed that during the catagen phase, the inner root sheath of hair follicles becomes an early target, highlighting its potential role in maintaining hair follicle homeostasis.
This article discusses functional thyroid disorders, their symptoms, and causes, without presenting new clinical results; it describes hypothyroidism and hyperthyroidism manifestations and explores the prevalence of thyroid nodules.
October 2024 in “Journal of the Endocrine Society” This case report highlights that a patient with resistance to thyroid hormone was misdiagnosed as having Graves’ disease, leading to unnecessary radioactive iodine treatment.
September 2021 in “International journal of Ayurveda and pharma research” In this case report, a patient with subclinical hypothyroidism exhibited a significant reduction in TSH levels after four months of ayurvedic treatment, but levels slightly increased afterward.
40 citations
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March 2019 in “Nature Communications” This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
32 citations
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January 2017 in “Orphanet journal of rare diseases” This article reviews the genetic basis, diagnostic approaches, and treatment options for nude severe combined immunodeficiency, but does not present any new research findings.
April 2006 in “Pediatrics in Review” This review covers the diagnosis and management of childhood Graves disease, emphasizing treatment options such as antithyroid medications, radioiodine therapy, and surgical thyroidectomy, and highlights the necessity for lifelong follow-up.
24 citations
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September 2014 in “PloS one” This study demonstrated that thyroid hormone receptors play a crucial role in hair growth and skin health, as mice lacking these receptors showed impaired hair cycling and wound healing.
November 2022 in “Journal of the Endocrine Society” This case study highlighted that excessive iodide intake from the supplement TauriNac was associated with the development of hypothyroidism in a cystic fibrosis patient, which reversed upon discontinuation.
June 2020 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, the authors observed that controlled microflora in gnotobionts leads to delayed maturation of T-dependent lymphocytes in the thymus, affecting cellular immunity reactions.
July 2024 in “Journal of Investigative Dermatology”
July 2018 in “International Journal of Research in Dermatology” This case report describes a 46-year-old female diagnosed with hypothyroidism, presenting with symptoms including severe hair loss, and treated with levothyroxine and supplements.
July 2025 in “International Journal of Homoeopathic Sciences” In this report, a 47-year-old woman with subclinical hypothyroidism experienced significant symptom relief and normalized TSH levels after six months of individualized homeopathic treatment with Sepia 1M, targeted to her symptom profile.
4 citations
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July 2014 in “Journal of Investigative Dermatology” This study suggests that age-related regenerative decline in hair follicles may be due to an imbalance of signals affecting stem cell activation, with follistatin potentially promoting renewal.
1 citations
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October 2014 in “Journal of the American Geriatrics Society” This report describes a case of a 75-year-old woman whose diagnosis of hypopituitarism led to significant weight gain and improved physical function with treatment, highlighting the potential for overcoming frailty when investigating underlying causes in elderly patients.
14 citations
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February 2007 in “Irish Veterinary Journal” This study reported the first known case of tertiary hypothyroidism in a dog, diagnosed after a Labrador treated for hyperadrenocorticism presented with related symptoms and an MRI-revealed pituitary mass.
March 2016 in “Indian Journal Of Applied Research” This report presents a case of refractory thyrotoxicosis where the patient required a total thyroidectomy after resistance to conventional treatments including antithyroid drugs and radioactive iodine.
6 citations
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January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.
5 citations
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June 2022 in “Frontiers in immunology” This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.
18 citations
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January 2017 in “Annals of dermatology/Annals of Dermatology” This study found that Th17 lymphocytes may play a more crucial role than cytotoxic T cells in the development of alopecia areata due to their infiltration around the hair bulb/bulge, which exacerbates hair loss as histopathological grade worsens.
11 citations
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July 1968 in “JAMA” This letter describes a case where a 43-year-old woman experienced severe itching as the presenting symptom of hyperthyroidism, alongside hair loss and other hyperthyroid features.
January 2025 in “Mansoura Medical Journal” This research observed that some hypothyroid patients on adequate levothyroxine therapy continue to experience symptoms like poor concentration and hair loss, with findings suggesting an elevated anti-TPO level increases the likelihood of such symptoms, despite normal TSH levels.
1 citations
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October 2022 in “international journal of endocrinology and metabolism” This study found that patients with hypothyroidism and hair loss exhibited significant differences in dermoscopic findings, including hair shaft abnormalities and vascular changes, compared to euthyroid individuals.
12 citations
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April 2017 in “Experimental and Therapeutic Medicine” This study found that patients with active severe alopecia areata exhibited decreased CD200 expression on T and B lymphocytes, which may be linked to an imbalance in Th1/Th2 immune equilibrium.
96 citations
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December 2018 in “Immunity” This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.
October 2024 in “Journal of the Endocrine Society” This case report describes a rare conversion from Hashimoto's thyroiditis to Graves' disease in a 23-year-old male, requiring a shift from levothyroxine to methimazole and eventually radioactive iodine therapy.
April 2018 in “Journal of Investigative Dermatology” In this study, TRPV3G568V mice exhibited periodic hair loss and immune cell infiltration in the dermis, without affecting hair follicle stem cell fate, suggesting a focus on dermal immune cells for future research.
64 citations
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May 2000 in “International Journal of Dermatology” This study found that thalidomide increased peripheral lymphocyte counts and reduced inflammation in lupus erythematosus patients, but was associated with polyneuropathy, suggesting careful use in refractory cases.