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This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells.

This study found that human hair follicle dermal papilla cells cultivated as 3D spheroids in hexanoyl glycol chitosan-coated dishes formed hair-like structures, with minoxidil enhancing growth, and successfully integrated into artificial skin models, suggesting advancements for hair loss treatments and skin restoration therapies.

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.

This study found that CD133-positive dermal papilla cells significantly enhanced hair growth in mice compared to CD133-negative cells, suggesting their potential for improving human hair follicle engineering.

Three-dimensional culture helps dermal papilla cells grow new human hair follicles.

This abstract omits specific findings and does not provide new research results.

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

This study found that a 3D Matrigel culture technique for dermal papilla cell spheroids can enhance hair follicle inductivity and induce hair-like fiber differentiation in vitro, even with high-passage cells.

This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.

This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.

In this study, researchers demonstrated that using 3D spheroid formation and genetic modification significantly enhanced the hair-inducing capacity of human dermal papilla cells in engineered skin constructs.

This study suggests that promoting HIF-1a expression in dermal papilla cells could enhance trichogenic gene expression, offering a potential therapeutic target for hair loss treatment.

STAT5 is crucial for hair growth in 3D cultured human dermal papilla cells.

This study investigated the use of 3D cell culture technology to explore hair follicle regeneration, examining the impact of the 3D cellular environment on hair follicle morphogenesis and the effects of microwell depth on spheroid formation.

This study suggests the possibility of regenerating hair follicle structures in vitro using hiPSC-derived cell composites, which might reduce reliance on human tissue-derived cells for hair bioengineering.

This study found that silibinin may promote hair growth by increasing proliferation and activating the AKT and Wnt/β-catenin signaling pathways in 3D cultured human dermal papilla spheroids.

Erythropoietin can promote hair growth by increasing IGF-1 in hair cells.

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.

This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.

This study found that 5% activated platelet-rich plasma significantly improved cell proliferation and hair-inductive ability of dermal papilla cells in vitro, and promoted hair follicle formation in mice.

This study demonstrated that culturing high-passage dermal papilla cells with specific supplemented conditioned media may preserve their hair-inducing abilities, suggesting potential for reconstructing new hair follicles in vivo.

This review discusses the regenerative potential of hair follicle stem cell populations and current approaches to reconstructing folliculogenesis for alopecia therapy, but reports no new clinical results.

This study found that suspension culture was more effective than hydrogel-based systems for maintaining spheroid morphology and differentiation of human iPSC-derived definitive endoderm cells.

This study found that non-balding dermal papilla cells emphasized extracellular matrix organization and reduced inflammation when cultured in 3D or with adipose-derived stem cells, unlike balding cells which maintained inflammatory pathways.

This review discusses strategies for hair follicle regeneration using tissue engineering and reports no new clinical results; the authors highlight potential future directions for promoting hair neoformation.

This study found that cultured human dermal papilla cells formed into three-dimensional spheres have an increased ability to induce hair follicles from mouse epidermal cells compared to two-dimensional cultures.

This study demonstrates that incorporating human neopapilla into reconstructed human skin can initiate hair follicle morphogenesis by stimulating epidermal invagination and maintaining follicle-inductive properties in vitro.