Hypoxia Inducible Factor-1a Promotes Trichogenic Gene Expression in Human Dermal Papilla Cells

    November 2022 in “ Research Square (Research Square) ”
    Jieun Seo, Lu Yan, Tatsuto Kageyama … Junji Fukuda

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study suggests that promoting HIF-1a expression in dermal papilla cells could enhance trichogenic gene expression, offering a potential therapeutic target for hair loss treatment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads Journal of Bioscience and Bioengineering · 2022
    2. The Effect of Hypoxia on the Proliferation Capacity of Dermal Papilla Cells by Regulating Lactate Dehydrogenase Journal of Cosmetic Dermatology · 2020
    3. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    4. Hypoxia Improves Hair Inductivity of Dermal Papilla Cells via Nuclear NADPH Oxidase 4-Mediated Reactive Oxygen Species Generation British Journal of Dermatology · 2019
    5. Novel Effect of Sildenafil on Hair Growth Biochemical and Biophysical Research Communications · 2018
    6. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    7. Regenerative Medicine and Hair Loss: How Hair Follicle Culture Has Advanced Our Understanding of Treatment Options for Androgenetic Alopecia Regenerative Medicine · 2013
    8. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    9. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    10. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    11. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    12. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    13. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

    Related research 7

    1. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    2. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    3. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    4. Hair Follicle Reformation Induced by Dermal Papilla Cells from Human Scalp Skin Archives of Dermatological Research · 2006
    5. Study on Hair Follicle Formation Induced by Dermal Papilla Cells Chinese Journal of Reparative and Reconstructive Surgery · 2003
    6. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    7. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998