Hypoxia Inducible Factor-1a Promotes Trichogenic Gene Expression in Human Dermal Papilla Cells
November 2022
in “
Research Square (Research Square)
”
TLDR A protein called HIF-1a helps control hair growth genes and could be targeted to treat hair loss.
The study found that hypoxia-inducible factor-1a (HIF-1a), a protein, is suppressed in the scalp tissues of patients with androgenetic alopecia, a common form of hair loss. This suppression was associated with hair follicle development. When HIF-1a was reduced in dermal papilla cells (DPCs), which are crucial for hair growth, the expression of hair growth-related genes decreased. This was observed in a simulated in vivo environment using a three-dimensional spheroid culture. However, when a HIF-1a activator was used, the expression of these hair growth-related genes increased. This suggests that HIF-1a plays a significant role in regulating hair growth genes and could be a potential target for treating hair loss.
View this study on researchsquare.com →
Cited in this study
12 / results
research Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads
Activating the PI3K/Akt pathway improves hair growth by human dermal papilla cells in hair beads.
research Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine
Researchers developed a method to grow hair follicles using special beads that could help with hair loss treatment.
research Hypoxia Improves Hair Inductivity of Dermal Papilla Cells via Nuclear NADPH Oxidase 4-Mediated Reactive Oxygen Species Generation
Low oxygen levels can make hair-growing cells better at growing hair through a process involving reactive oxygen species.
research Novel Effect of Sildenafil on Hair Growth
Sildenafil, often used for erectile dysfunction, may help hair growth.
research Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration
Technique creates 3D cell spheroids for hair-follicle regeneration.
research Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia
Hair follicle culture helps develop new treatments for hair loss.
research Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
Growing human skin cells in a 3D environment can stimulate new hair growth.
research Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research The Hair Follicle as a Dynamic Miniorgan
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Molecular mechanisms of androgenetic alopecia
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
research Molecular Mechanisms Regulating Hair Follicle Development
Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
Related
6 / results
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
research A model system to analyse the ability of human keratinocytes to form hair follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research STUDY ON HAIR FOLLICLE FORMATION INDUED BY DERAMAL PAPILLA CELL
Dermal papilla cells can help form hair follicles and produce hair.
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.