39 citations,
May 2014 in “Frontiers in Pharmacology” Special immune cells called Tregs can help prevent lung scarring by blocking a specific growth factor.
28 citations,
March 2017 in “Endocrinology” Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.
25 citations,
September 2018 in “Molecular Biology of the Cell” Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.
25 citations,
August 2010 in “Journal of Biological Chemistry” Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.
24 citations,
December 2014 in “International Journal of Molecular Medicine” Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.
14 citations,
January 2017 in “Pharmacological Reports” TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.
14 citations,
January 2006 in “Skin pharmacology and physiology” Procyanidin compounds from apples and barley promote hair growth and prevent hair cell death.
4 citations,
July 2020 in “Biochemical and Biophysical Research Communications” A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.
Alopecia areata patients have higher levels of certain immune receptors, suggesting new treatment possibilities.
August 2023 in “Research Square (Research Square)” Two microRNAs affect hair follicle development in sheep by targeting specific genes.
122 citations,
July 2005 in “The FASEB journal” Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.
119 citations,
November 2014 in “Trends in Cell Biology” Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.
108 citations,
September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” Lowering testosterone speeds up wound healing in male mice.
91 citations,
May 2003 in “American Journal of Pathology” Prolactin affects hair growth cycles and can cause early hair follicle regression.
83 citations,
December 2001 in “Journal of Investigative Dermatology” Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
60 citations,
May 2015 in “Archives of dermatological research” PPAR agonists show promise for skin conditions but need more research before being a main treatment.
30 citations,
November 2013 in “PLOS ONE” Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
27 citations,
February 2014 in “Planta Medica” Scutellaria baicalensis extract and baicalin may help prevent hair loss.
26 citations,
May 2012 in “Cellular and Molecular Life Sciences” NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.
23 citations,
January 2021 in “Biomedicine & Pharmacotherapy” DHT stops hair regrowth in mice, similar to human hair loss.
23 citations,
September 2015 in “International Journal of Molecular Medicine” Activating ER-β, not ER-α, improves skin cell growth and wound healing.
18 citations,
February 2018 in “International Journal of Molecular Sciences” PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
18 citations,
January 2017 in “Postępy Dermatologii i Alergologii” EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.
18 citations,
January 2008 in “Journal of The American Academy of Dermatology” Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.
9 citations,
January 2016 in “Skin Pharmacology and Physiology” The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.
8 citations,
March 2020 in “Frontiers in Cell and Developmental Biology” Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.
4 citations,
October 2007 in “Dermatologic Clinics” Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.
1 citations,
January 2021 in “Journal of biological chemistry/The Journal of biological chemistry” FLCN helps control iron levels in cells.
1 citations,
January 2019 in “Skin Pharmacology and Physiology” Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.