115 citations
,
February 2016 in “Nature Communications” The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.
115 citations
,
August 2008 in “The Journal of Clinical Endocrinology & Metabolism” In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.
111 citations
,
June 2002 in “The EMBO Journal” This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.
109 citations
,
December 2003 in “American Journal of Pathology” This study observed that the ontogenetic transition from scarless repair in early fetal rat wounds to scar-forming repair in late gestation is associated with differential TGF-β ligand and receptor expression patterns.
105 citations
,
February 1996 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, sequences upstream of the TGM3 gene were found to regulate epithelial-specific gene expression in keratinocytes, suggesting potential applications in gene therapy.
103 citations
,
January 2006 in “Journal of Cell Science” This review summarizes the major events and regulators of the hair cycle in mammals but reports no new experimental results; it emphasizes the complex regulation of stem cell activation and differentiation during hair growth.
96 citations
,
December 2018 in “Immunity” This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.
92 citations
,
June 2005 in “Journal of Investigative Dermatology” This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.
91 citations
,
July 2022 in “Frontiers in Endocrinology” This study reported that Chinese women with PCOS exhibited diverse lipid profiles based on different characteristics, which may help understand their increased risk of cardiovascular disease.
91 citations
,
March 1996 in “Archives of Dermatological Research” This study concluded that cytokines and growth factors significantly regulate hair growth in vitro, with some completely inhibiting growth, such as EGF and TNFα.
90 citations
,
October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
86 citations
,
July 2020 in “International Journal of Molecular Sciences” This review discusses the role of Wnt/β-catenin signaling in hair follicle regeneration and highlights recent progress in developing hair loss treatments targeting this pathway, but reports no new clinical results.
86 citations
,
May 2008 in “Cytokine & growth factor reviews” This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.
84 citations
,
January 2018 in “Biomaterials Science” Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.
83 citations
,
May 2013 in “International Journal of Molecular Sciences” This review explores embryonic epidermal development and discusses key molecular regulators and roles of the sub-epidermal mesenchyme, but reports no new experimental results.
81 citations
,
September 2005 in “The American journal of pathology” This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.
81 citations
,
January 2003 in “The FASEB Journal” This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.
79 citations
,
December 1990 in “Clinical endocrinology” This review explores the mechanisms of intratesticular control of steroidogenesis and indicates the need for further controlled studies; it presents no new experimental findings.
78 citations
,
June 2021 in “Dermatology and Therapy” This study highlights the evolving understanding of acne's pathophysiology and suggests that targeting pro-inflammatory cytokines such as IL-1β, IL-17, IL-23, and TNFα with biological antibodies may offer new treatment strategies for severe acne and its scars.
77 citations
,
June 2007 in “PLoS ONE” This study identified changes in transcription factor gene expression across various signaling pathways during inner ear hair cell regeneration in birds, revealing patterns and potential new pathways for future investigation.
76 citations
,
May 2007 in “Menopause International” This review discusses the relationship between estrogen deficiency and skin aging in postmenopausal women, noting potential benefits of estrogen use on skin collagen and elasticity, but reports no new clinical results.
74 citations
,
June 2021 in “Frontiers in Cell and Developmental Biology” This study suggests that exosomal miRNAs from human amniotic fluid stem cells may inhibit myofibroblast differentiation and reduce fibrotic scarring in wound healing.
72 citations
,
July 2014 in “American journal of clinical dermatology” This review analyzed randomized controlled trials on alopecia areata treatment and found that while several treatments showed effectiveness, most studies had limitations affecting their interpretability.
72 citations
,
October 2009 in “The FASEB journal” This study found that thyrotropin-releasing hormone (TRH) acts as a potent stimulator of hair growth in human scalp hair follicles, promoting elongation and prolonging the anagen phase.
71 citations
,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses the role of Edar signaling in hair follicle development and cycling, emphasizing its impact on cell fate, differentiation, and interactions with other pathways, but reports no new results.
70 citations
,
March 2002 in “Journal of Burn Care & Rehabilitation” This study found that HB-EGF and TGF-α work together to stimulate wound healing in a murine model of thermal injury, with peak keratinocyte proliferation observed by postburn day five.
69 citations
,
August 1999 in “Developmental biology” This study found that ectopic expression of Whn in transgenic mice caused impaired differentiation in epidermis and hair follicles, with hair growth defects and severe urinary tract issues leading to hydronephrosis.
68 citations
,
April 2012 in “Journal of Investigative Dermatology” The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.
67 citations
,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that in vitro, beard dermal papilla cells stimulated keratinocyte proliferation via androgen-dependent growth factors, while androgenetic alopecia cells released TGF-β1, inhibiting keratinocyte growth.
66 citations
,
January 2020 in “Acta Dermato Venereologica” This article reviews genetic advances in resolving inherited ichthyoses using next generation sequencing and notes that new sequencing methods may clarify unknown types in the future.