Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

    June 2007 in “ PLoS ONE ”
    R. David Hawkins, Stavros Bashiardes, Kara E. Powder, Samin A. Sajan, Veena Bhonagiri, David M. Alvarado, Judith D. Speck, Mark E. Warchol, Michael Lovett
    TLDR Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.
    The study investigated the gene expression profiles during the regeneration of inner ear sensory hair cells in avian species, which unlike mammals, can regenerate these cells. Using cross-species microarrays, the research examined over 1700 transcription factor genes in auditory and vestibular organs after damage and regeneration. It identified components of seven known signaling pathways, including TGFbeta, NOTCH, and WNT, and noted differential expression in apoptotic and cell cycle control pathways. The study also found identical expression patterns across tissues and treatments during regenerative proliferation and highlighted the involvement of estrogen receptor signaling and circadian rhythm genes. Notably, 45 zinc finger genes were up-regulated at later stages of cochlear regeneration. These findings provided a foundation for further exploration of the pathways involved in hair cell recovery and their interactions.
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