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Glossary Circadian Rhythms

natural, internal processes regulating sleep-wake cycles every 24 hours

Circadian rhythms are natural, internal processes that regulate the sleep-wake cycle and repeat roughly every 24 hours. These rhythms are driven by the body's "biological clock," which is influenced by external cues like light and temperature, and they play a crucial role in determining sleep patterns, feeding behavior, hormone release, and other bodily functions.

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Research

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Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

research Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor

62 citations , August 2014 in “BMC Endocrine Disorders”

This review summarizes the recent advances in molecular mechanisms influencing tissue sensitivity to glucocorticoids, emphasizing novel mutations and new information on the glucocorticoid receptor's circadian rhythm and ligand-induced repression, but reports no new results.

Circadian Rhythm Sleep-Wake Disorders: Linking Circadian Misalignment to Adverse Health Outcomes

research Circadian rhythm sleep-wake disorders (CRSWDs): Linking circadian misalignment to adverse health outcomes.

5 citations , November 2020 in “EBioMedicine”

This study reports a novel diagnostic method for latent circadian rhythm sleep-wake disorder using circadian gene oscillations from hair follicle cells to improve sleep disorder differentiation and potential therapeutic intervention.

research The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

January 2024 in “Cells”

This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.

research An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression

21 citations , September 2013 in “Journal of circadian rhythms”

In this study, heavy nighttime physical exercise delayed the circadian phase of clock gene expression by 2 to 4 hours in a professional fighter, suggesting potential implications for managing circadian disorders.

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

77 citations , June 2007 in “PLoS ONE”

This study identified changes in transcription factor gene expression across various signaling pathways during inner ear hair cell regeneration in birds, revealing patterns and potential new pathways for future investigation.

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Community Join

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community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 4 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

community How long does it take after an environmental / lifestyle change for hair loss to actually slow down?

5 upvotes 11 months ago

Lifestyle changes may not significantly impact hair loss, as factors like DHT and genetics play a larger role. Some users suggest treatments like finasteride, dutasteride, and microneedling for hair growth.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Does Creatine Really Increase DHT? My Personal Experiment

115 upvotes 1 year ago

Creatine does not increase DHT levels, but some report hair loss when using it, possibly due to other factors. The effects on hair loss vary individually, with no clear connection established.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

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Learn

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learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

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Clinics

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24
Trichology
Hair Rhythm Hair Restoration SalonKato · JP

Experts

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi