46 citations
,
September 2016 in “Clinical, Cosmetic and Investigational Dermatology” This article reviews the hormonal pathogenesis and treatment strategies for acne vulgaris, particularly in women with severe or treatment-resistant cases, associating it with hormonal imbalances and hyperandrogenism.
35 citations
,
May 2020 in “Frontiers in Pharmacology” This review provides a comprehensive overview of the mechanisms, efficacy, and adverse reactions of drugs commonly used for treating benign prostatic hyperplasia but reports no new clinical results.
30 citations
,
December 2001 in “Journal of The European Academy of Dermatology and Venereology” This paper discusses hormonal therapy options for women with severe acne, focusing on treatment for cases that do not respond to conventional methods, but it reports no new clinical findings.
21 citations
,
February 2017 in “International Journal of Women's Dermatology” This review discusses the physiology and potential hormonal mechanisms involved in female pattern hair loss, as well as the current hormonal and hormone-modifying treatments available, but reports no new research findings.
20 citations
,
August 2019 in “Expert Opinion on Drug Safety” This review examines the cognitive effects of medications for lower urinary tract symptoms and indicates that muscarinic antagonists, particularly oral oxybutynin, pose the highest risk for cognitive impairment.
16 citations
,
February 2018 in “European Journal of Endocrinology” This review discusses the challenges in measuring testosterone for assessing androgen excess in women and emphasizes the importance of quality control in laboratory methods, but it reports no new clinical results.
9 citations
,
January 1997 in “Gynecological Endocrinology” This review discusses the regulation of hair growth, causes of excessive androgen secretion, and current safe solutions for hyperandrogenism manifestations in women but reports no new clinical results.
5 citations
,
August 2023 in “The World Journal of Men s Health” This study found that red ginseng oil (RXGIN) significantly improved lower urinary tract symptoms and some aspects of sexual function in men, with no serious adverse events reported.
March 2016 in “Korean Journal of Medicine” This study reported that doxazosin may result in gynecomastia after administration but evidence and expert reviews on this are still lacking domestically.
April 2008 in “Obstetrics, gynaecology and reproductive medicine” This article reviews the diagnosis and management of hirsutism in women, discussing its causes, assessment, and treatment options; no new clinical findings are included.
18 citations
,
July 2020 in “Basic and Clinical Andrology” This article discusses concerns and recommendations from a French-speaking andrology society regarding COVID-19's potential impact on men's reproductive health and calls for further research in this area.
17 citations
,
April 1997 in “Archives of dermatology” This case report describes the treatment of hirsutism in a 15-year-old obese Mexican girl with flutamide, aiming to improve her social function.
January 2023 in “Iranian Journal of Pharmaceutical Research” This study concluded that S. hexaphylla extract may improve androgenetic alopecia by reducing 5α-reductase and androgen receptor levels, inhibiting apoptosis, and promoting keratinocyte proliferation in experimental models.
January 2026 in “Regenerative Therapy” Low-frequency electromagnetic fields may help treat hair loss by promoting hair regrowth.
20 citations
,
January 2004 in “PubMed” This review discusses the pharmacologic effects, safety, and efficacy of dutasteride and finasteride for BPH, finding similar clinical benefits but greater DHT reduction with dutasteride and reports no new trial results.
August 2010 in “한국한의학연구원 논문집” In this animal study, Phellodendri Cortex extract reduced prostate tissue damage and inhibited 5α-reductase gene expression in rats with experimentally induced benign prostatic hyperplasia.
33 citations
,
July 2009 in “Therapeutics and Clinical Risk Management” This review discusses the use of finasteride for treating benign prostatic hyperplasia and highlights its potential for reducing prostate size, symptom control, and lowering the risk of surgery and urinary retention.
6 citations
,
November 2018 in “Journal of molecular histology” This animal study found that testosterone treatment increased vas deferens fluid secretion rate in rats, with potential implications for male fertility through the upregulation of AQP-1, 2, and 9 proteins.
6 citations
,
August 2021 in “Clinical Epidemiology” Men using 5-alpha reductase inhibitors for prostate issues may have a slightly higher risk of blood clots.
March 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Dutasteride helps reduce male pattern hair loss, but may cause side effects like altered libido and erectile dysfunction.
July 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that adding pioglitazone to either spironolactone or metformin improved metabolic parameters and insulin resistance in women with PCOS, despite an increase in BMI.
1 citations
,
April 2022 in “Emergency Medicine Australasia” This article discusses the negative experiences transgender individuals often encounter in emergency healthcare settings and emphasizes the importance of gender-affirming practices, but it reports no new clinical results.
60 citations
,
July 2018 in “Circulation” This study found that hypogonadism in men can be a reversible risk factor for torsades de pointes (TdP), with testosterone replacement potentially preventing TdP recurrence.
57 citations
,
April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.
45 citations
,
September 2000 in “Archives of dermatology” This study found that 5alpha-reductase type 1 localizes specifically to sebaceous glands in both normal and acne follicles, suggesting its role in sebum regulation.
25 citations
,
September 2014 in “Pharmacotherapy” This review covers cross-sex hormone therapy for gender dysphoria, noting improvements in psychological symptoms and quality of life but lacking definitive long-term safety data.
5 citations
,
January 2017 in “Acta Endocrinologica” This case report discusses a postmenopausal woman whose hyperandrogenism and metabolic symptoms improved significantly after the surgical removal of an ovarian Leydig cell tumor, confirmed post-operatively.
4 citations
,
August 2021 in “Annals of Translational Medicine” In this study, dihydroartemisinin reduced prostate enlargement and related markers in a rat model of benign prostatic hyperplasia, suggesting its potential as a therapeutic agent.
2 citations
,
November 2023 in “International Journal of Preventive Medicine and Health (IJPMH)” This study explored the effects of a 50% hydroalcoholic UPBF extract on BPH in testosterone propionate-induced rats, finding significant improvements in prostate-related parameters and lower urinary tract symptoms at a 200 mg/kg dose, suggesting potential use in BPH management.
1 citations
,
March 2022 in “British Journal of Clinical Pharmacology” In this study, the use of 5-α reductase inhibitors was not associated with an increased risk of anaemia compared to α-blockers in men with benign prostatic hyperplasia.