The Risk of Venous Thromboembolism in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors

    August 2021 in “ Clinical Epidemiology ”
    Olulade Ayodele, Howard Cabral, David D. McManus, Susan S. Jick
    TLDR Men using 5-alpha reductase inhibitors for prostate issues may have a slightly higher risk of blood clots.
    The study examined the risk of venous thromboembolism (VTE) in 91,115 men aged 40–79 with benign prostatic hyperplasia (BPH) treated with 5-alpha reductase inhibitors (5ARIs) compared to those using alpha-blockers (ABs) only. It found a slightly elevated risk of VTE in users of 5ARIs, particularly in those with high cumulative doses, with an adjusted odds ratio (aOR) of 2.29 for individuals with 50 or more prescriptions. The study suggested that excessive inhibition of dihydrotestosterone (DHT) might contribute to this increased risk and emphasized the need for further research to clarify the potential VTE risk associated with 5ARI use.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community Wtf have we been doing for the last 30 years

      in Treatment  548 upvotes 11 months ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

      community Update: 4 Month progress on Fin/Min plus dermaroller

      in Progress Pictures  559 upvotes 1 year ago
      A user shared a 4-month update on their hair regrowth progress using finasteride, minoxidil, a dermaroller, ketoconazole shampoo, multivitamins, and biotin, and received positive reactions and inquiries from others. They also mentioned lifestyle changes such as quitting creatine, alcohol, and smoking, which may have contributed to their success.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 1 year ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

    Related Research

    1 / 1 results