The Risk of Venous Thromboembolism in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors

    August 2021 in “ Clinical Epidemiology ”
    Olulade Ayodele, Howard Cabral, David D. McManus, Susan S. Jick
    Studysummary Men using 5-alpha reductase inhibitors for prostate issues may have a slightly higher risk of blood clots.
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    Research cited in this study 12

    1. Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use Yonsei Medical Journal · 2020
    2. Finasteride Induced Cerebral Venous Thrombosis Journal of the Korean neurological association · 2015
    3. Testosterone, Dihydrotestosterone, and Incident Cardiovascular Disease and Mortality in the Cardiovascular Health Study ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2014
    4. Two Cases of Stroke Associated with the Use of Finasteride, an Approved Drug for Male-Pattern Hair Loss in Japan Rinshō shinkeigaku · 2014
    5. Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review Sexual medicine reviews · 2013
    6. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    7. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    8. Finasteride and Male Breast Cancer: Does the MHRA Report Show a Link? PubMed · 2010
    9. Finasteride-Induced Gynecomastia: Case Reports and Review Indian Journal of Dermatology, Venereology and Leprology · 2009
    10. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    11. Unilateral Gynecomastia Induced by Treatment with 1 mg of Oral Finasteride Archives of Dermatology · 2002
    12. Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study Steroids · 1998

    Related research 1

    1. Change in Hair Growth-Related Gene Expression Profile in Human Isolated Hair Follicles Induced by 5-Alpha Reductase Inhibitors – Dutasteride and Finasteride – in the Presence of Testosterone Singapore Medical Journal · 2021