Low-Frequency Electromagnetic Fields Ameliorate Testosterone-Induced Androgenetic Alopecia in Mice Through LncRNA H19/miR-214-5p/β-Catenin Signal Pathway

    January 2026 in “ Regenerative Therapy ”
    Jianghua Cheng, Chong-You, Ting Hu, Wei-Jun Fang, Xiao-Min Niu, Ketao Du
    TLDR Low-frequency electromagnetic fields may help treat hair loss by promoting hair regrowth.
    The study explores the impact of low-frequency electromagnetic fields (LFEMFs) on testosterone-induced androgenetic alopecia (AGA) in mice, highlighting the LncRNA H19/miR-214-5p/β-catenin signaling pathway. Involving 40 mice and a clinical study with 30 male AGA patients and 30 healthy controls, the research found that LFEMF exposure significantly improved hair loss by modulating the expression of miR-214-5p, H19, and β-catenin. LFEMFs enhanced hair follicle stem cell proliferation, reduced apoptosis, and activated the Wnt/β-catenin pathway, suggesting their potential as a therapeutic approach for AGA. However, further research is needed to confirm the long-term safety and mechanisms of LFEMFs.
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