51 citations
,
February 2009 in “Journal of dermatological science” In this study, β-catenin overexpression in human hair outer root sheath cells increased the expression of Pitx2, which activated the follicular differentiation pathway, suggesting Pitx2's potential role as a modulator in hair growth control.
47 citations
,
August 2000 in “Endocrine Reviews” This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.
39 citations
,
August 2022 in “Cell Death and Disease” This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.
38 citations
,
August 2012 in “Biochemical and biophysical research communications” This study found that leukocytes and beard hair follicle cells have an endogenous circadian clock, with PER1 and PER3 expression possibly serving as biomarkers for assessing individual biological clock traits.
38 citations
,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
36 citations
,
October 2016 in “Medical mycology” This study at Mbarara University of Science and Technology found that T. violaceum is the most common cause of tinea capitis in children in Western Uganda, and systemic therapy is preferred over topical treatments for effective management due to the nature of the infection.
36 citations
,
March 2002 in “Journal of Biological Chemistry” Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.
34 citations
,
March 2004 in “Journal of Liposome Research” This study found that neutral liposomes were most effective at delivering minoxidil into pilosebaceous units compared to other tested formulations.
33 citations
,
February 2016 in “Journal of Experimental Botany” This study found that the receptor kinase RHS10 negatively regulates root hair growth in Arabidopsis thaliana by modulating growth duration and is associated with cell wall signal mediation, involving RNA catabolism and ROS accumulation.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
30 citations
,
June 2015 in “Dermatologic Surgery” This abstract does not provide any new research findings or results.
29 citations
,
January 2014 in “Frontiers in physiology” This review examines the molecular mechanisms of the circadian clock and its effects on cardiovascular functions, proposing a novel non-invasive method using hair follicle cells to assess circadian regulation in humans, but reports no new clinical results.
28 citations
,
March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
28 citations
,
January 2004 in “British Journal of Pharmacology” This study found that minoxidil provides cardioprotective effects in guinea-pig heart cells through selective activation of mitochondrial ATP-sensitive potassium channels.
25 citations
,
May 1994 in “Journal of Investigative Dermatology” This study identified a novel gene, hacl-1, that is specifically expressed in the hair follicles of ICR mouse skin and is associated with their active state.
23 citations
,
December 2017 in “Scientific Reports” This study found that the ARL15 gene affects adipocyte differentiation and adiponectin secretion, and suggests that ARL15 haploinsufficiency may predispose individuals to lipodystrophy.
22 citations
,
January 2017 in “Advanced Healthcare Materials” This study found that thermoresponsive hydrogels can maintain mechanical memory in fibroblasts, enhancing wound healing compared to traditional trypsinized methods.
18 citations
,
June 1995 in “International Journal of Dermatology” Women experience various skin issues at different life stages, requiring careful treatment and awareness.
17 citations
,
April 2021 in “Biointerface Research in Applied Chemistry” This review discusses nanostructured lipid carriers and their potential applications in pharmaceuticals and food, offering no new clinical findings but highlighting recent advancements and patents.
16 citations
,
December 2019 in “Animals” In this study, cashmere goats engineered to overexpress the Tβ4 gene in hair follicles produced more cashmere, indicating that Tβ4 promotes secondary hair follicle development and enhances yield.
16 citations
,
March 2008 in “International journal of pharmaceutics” This study found that formulation factors like pH, viscosity, and chemical enhancers can significantly influence intrafollicular hydrocortisone permeation in vitro, with higher pH and enhancers reducing follicular contribution.
16 citations
,
March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.
14 citations
,
February 2021 in “International Journal of Pharmaceutics” In this study, applying deer antler velvet extract-loaded niosomes and microspicules serum to the scalp significantly improved hair growth, melanin content, and skin hydration over 14 to 30 days without causing skin irritation.
12 citations
,
February 1998 in “Gene” This study identified two high sulfur protein genes, B2E and B2F, in rats, which are expressed in hair cortical cells during anagen and contribute to hair fiber production.
12 citations
,
June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.
11 citations
,
December 2020 in “Notulae botanicae Horti Agrobotanici Cluj-Napoca” This study found that arbuscular mycorrhizal fungus inoculation and shading improved tea seedlings' growth, nutrient absorption, and stress resistance by enhancing root biomass and regulating phytohormone levels and gene expression.
11 citations
,
January 2008 in “International journal of environment and health” This review discusses the environmental contamination and health risks of Platinum Group Elements, highlighting their potential bioaccumulation and associated health issues, especially in vulnerable populations like children, and reports no new experimental findings.
11 citations
,
July 2016 in “Endocrinology” This study found that higher Lnk expression in PCOS patients may contribute to insulin resistance by inhibiting insulin signaling pathways.
10 citations
,
March 2014 in “Scandinavian journal of clinical and laboratory investigation” This study found that MDA-modified DNA may contribute to immune responses in alopecia areata patients by creating neo-epitopes, providing new insights into the condition's immunological mechanisms.
9 citations
,
April 2019 in “International Journal of Molecular Sciences” This research indicates that KCED-1 and KCED-2 effectively induce adiponectin production in human subcutaneous fat, which may promote hair growth on the scalp.