60 citations
,
August 1969 in “British Journal of Dermatology” This study used an autoradiographic technique to observe that germicides in surfactants are primarily deposited on the stratum corneum of guinea-pig and human skin.
29 citations
,
June 2014 in “Drug delivery” This study reported that nanoemulsions significantly improved the skin permeability of thiocolchicoside compared to its aqueous solution, suggesting they are effective carriers for its transdermal delivery.
10 citations
,
October 2023 in “Indian Dermatology Online Journal” In this study, the researchers highlighted the availability of new topical and systemic agents with varied mechanisms for treatment, emphasizing that the choice of agent should be tailored to individual needs and the options available in different countries.
4 citations
,
December 2023 in “Frontiers in Pharmacology” This study found that topical metformin was as effective as triple combination cream in reducing melasma severity, with minimal adverse events.
February 2025 in “Archives animal breeding/Archiv für Tierzucht” This study found that certain gene polymorphisms in keratin 27 and ELOVL4 are linked to improved cashmere fineness and production traits in Liaoning cashmere goats.
July 2024 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This review highlights encouraging findings on platelet-rich plasma's effectiveness in improving skin texture, firmness, and elasticity in aesthetic procedures but emphasizes the need for more standardized protocols and robust clinical trials.
This review critically analyzes recent literature on the use of nanotechnology in alopecia treatment, reporting promising results for improving drug delivery and hair growth, though challenges in maintaining physical stability may limit large-scale commercialization.
March 2023 in “Editora e-Publicar eBooks”
5 citations
,
September 2013 in “The Journal of Dermatology” Researchers found a new mutation in the HR gene causing hair loss and skin bumps in a Pakistani family.
November 2025 in “Indian Journal of Nephrology” In this case study, a 43-year-old male with anti-GBM disease experienced a relapse triggered by hair dye, leading to diffuse alveolar hemorrhage; managing this with plasmapheresis, intravenous immunoglobulins, and rituximab suggests rituximab may be beneficial for relapsing cases.
January 2026 in “Beilstein Journal of Organic Chemistry” This study developed a metal-free method for synthesizing sulfinimidate esters, showcasing their potential as versatile intermediates for enantioselective bond formation under mild conditions.
1398 citations
,
May 2008 in “Histochemistry and Cell Biology” This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.
343 citations
,
March 2016 in “Nature Communications” This study found that IL-17A-producing γδ T cells play a key role in bone fracture healing by promoting bone formation, with deficiencies leading to impaired repair in mice.
341 citations
,
November 2009 in “The FASEB Journal” This article reviews the multifunctional roles of calreticulin outside the ER and highlights its impact on wound healing in animal models, but reports no new clinical results.
321 citations
,
March 2015 in “Nature” This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.
308 citations
,
September 2010 in “Nucleic acids research” This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.
211 citations
,
October 2001 in “The FASEB Journal” This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.
195 citations
,
June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
188 citations
,
May 2009 in “Plant physiology” This study identified 19 specific genes involved in root hair growth and morphogenesis in Arabidopsis, using a combination of computational and experimental methods.
186 citations
,
July 1998 in “Journal of Cutaneous Medicine and Surgery” This study found that shorter CAG-repeat lengths in the androgen receptor may be associated with the development of androgen-mediated skin disorders like androgenetic alopecia, acne, and hirsutism in both men and women.
184 citations
,
September 2006 in “PLoS Genetics” This study found that loss of Apc due to K14-cre-mediated gene recombination in mice led to aberrant growth in ectodermally derived squamous epithelia, implicating its critical role in specifying epithelial cell fates during embryonic development.
174 citations
,
April 2005 in “The American journal of pathology (Print)” This study found that TRPV1 activation in human scalp hair follicles inhibited hair shaft elongation, suppressed proliferation, and induced apoptosis, suggesting TRPV1 as a potential target for managing hair growth and epithelial disorders.
169 citations
,
May 2006 in “Genes & Development” This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.
168 citations
,
August 2000 in “American Journal of Pathology” This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.
165 citations
,
September 2001 in “Genes & development” This study found that Cutl1 mutant mice experienced retarded lung differentiation and abnormal hair follicle morphogenesis, indicating the vital role of CDP in lung development and hair follicle cell-lineage specification.
137 citations
,
October 2009 in “The American journal of pathology” This study found that matriptase, a membrane serine protease, is crucial for maintaining multiple types of epithelial tissues in mice, with its absence leading to severe organ dysfunction and increased permeability.
131 citations
,
March 2004 in “The American journal of pathology” This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.
124 citations
,
September 1992 in “Endocrinology” This article discusses the structure of the human type II 5 alpha-reductase gene and reports no new experimental results.
123 citations
,
May 2009 in “Journal of Neuroscience” In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.
108 citations
,
July 2004 in “American Journal of Pathology” This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.