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The C-terminal tail of AHF/trichohyalin is essential for organizing keratin filaments in keratinocytes.

Researchers found that the most reachable bonds in wool fibers are near the ends of certain proteins, which help stabilize the fiber's structure.

Disulfide bonds in keratin fibers break more easily under stress, especially when wet, affecting fiber strength.

Understanding intermediate filaments helps explain hair health and related diseases.

The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.

A new mutation in the K6b gene caused a girl's late-appearing nail condition.

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.

Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.

High glycine–tyrosine keratin-associated proteins help make hair strong and maintain its shape.

Human hair keratin might be good for filtering out harmful substances from water.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Lamins are vital for cell survival, organ development, and preventing premature aging.

The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.

A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.

Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

New treatments targeting specific genes show promise for treating keratin disorders.

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

The HOXC13 gene affects different hair proteins in cashmere goats in varied ways and is controlled by a feedback loop and other factors.

K6hf is a unique protein found only in a specific layer of hair follicles.

Sphynx cats are hairless and Devon Rex cats have curly hair due to specific genetic mutations.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Keratins are important for skin cell health and their problems can cause diseases.

K16 can partially replace K14 but causes hair loss and skin issues.

Mutations in the KRT85 gene cause hair and nail problems.

Cysteine-rich keratins evolved independently in mammals, reptiles, and birds for hard skin structures like hair, claws, and feathers.

Hair's strength and flexibility come from its protein structure and molecular interactions.

Recombinant keratins can form useful structures for medical applications, overcoming natural keratin limitations.

An apple-based supplement was found to stimulate hair protein production, which may help with hair growth.