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This study found that thymus transplantation in athymic mice resulted in T-cell-driven hair follicle depigmentation and loss, without multiorgan autoimmune disease, highlighting mechanisms of tissue-specific tolerance.

In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.

This review examines the potential of CAR-T cell therapy as a transformative treatment for refractory autoimmune diseases, highlighting its mechanisms, clinical challenges, and promising strategies for precision immunotherapy despite issues like complex manufacturing and antigen escape.

This study found that despite the persistence of aberrant double-negative T-cells, functional immune-competence was maintained after thymic transplantation in a patient with a rare FOXN1 mutation.

This study suggests that targeting skin-infiltrated memory phenotype T cells could offer a new therapeutic approach to manage lymphopenia-related diseases like graft-versus-host disease and immune reconstitution inflammatory syndrome.

This study found that thymus transplantation in infants with FOXN1 deficiency led to T-cell reconstitution and functional immunity, resolving serious infections and cytopenias.

This study found that CMV infection in a mouse model of allogeneic transplantation was associated with increased allo-reactive T cell expansion and exacerbated graft-versus-host disease, highlighting the need for effective GvHD prophylaxis and treatment.

This study found that FOXN1 haploinsufficiency is a significant genetic factor causing T cell lymphopenia at birth, linked to reduced thymic function in both humans and mice.

In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.

This report presents a case where a patient with Omenn syndrome, complicated by cytomegalovirus infection, was successfully treated using reduced intensity conditioning allogeneic HSCT from a sibling donor.

In this study using the C3H/HeJ mouse model of alopecia areata, researchers found that hyperexpanded CD8⁺ T cell clones were sufficient to initiate disease, establishing a causal link between T cell clonality and pathogenicity.

This article reviews the history and characteristics of the rare nude phenotype SCID, primarily distinguished by severe T cell immunodeficiency and notable skin and hair abnormalities, but reports no new clinical findings.

This study found that epidermal melanocytes can regenerate hair follicles, whereas non-cutaneous or dermal melanocytes cannot, suggesting two distinct melanocyte lineages with potential implications for melanocyte-related diseases.

In this review, the authors discuss the potential for cell therapy, such as hematopoietic stem cell transplantation and mesenchymal stromal cells, to treat severe psoriasis unresponsive to biological therapies, while highlighting the associated risks, costs, and regulatory challenges.

This study found that interleukin-1α and interleukin-7 secreted by keratinocytes enhance the proliferation of γδT-cells and epidermal stem cells, revealing mechanisms of stem cell activation during wound healing in mice.

The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.

This study demonstrated that CD19-CAR T cell therapy may promote structural regeneration in the skin of systemic sclerosis patients, as evidenced by histological improvements and fibroblast population changes, suggesting its potential for tissue remodeling in fibrotic diseases.

This study established the R-7 dermal papilla cell line, which retained essential characteristics of primary cells without undergoing malignant transformation, suggesting its potential for future hair research.

This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.

This study found that IL-1α and IL-7 secreted from keratinocytes in a genetically engineered mouse model can stimulate the expansion of γδT-cells, aiding in the proliferation of epidermal stem cells for wound healing.

This study describes the process of isolating and analyzing multipotent stem cells from mouse hair follicles for potential use in tissue engineering and regenerative medicine.

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

In this study, researchers established five new immortalized human dermal papilla cell lines from a male with androgenetic alopecia, which may serve as valuable tools for hair research.

This study suggests that combining bendamustine with tucidinostat may improve survival in patients with relapsed or refractory adult T-cell leukemia/lymphoma, highlighting its potential for clinical investigation.

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.

This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.

This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.

This review summarizes recent findings on FOXN1's essential role in thymus and skin biology and discusses emerging therapeutic approaches for immune disorders with athymia, but reports no new clinical results.