TLDR T cells with memory features grow in number and gather around hair follicles when there are not enough immune cells.
The study titled "Expanded T cells under lymphopenic condition exhibit memory phenotype and infiltrate around hair follicle" investigates the behavior of T cells in a lymphopenic environment. The findings reveal that these T cells adopt a memory phenotype and tend to infiltrate the area surrounding hair follicles. This suggests a potential link between immune cell behavior and hair follicle health, which could have implications for understanding conditions like alopecia.
33 citations
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September 2017 in “Journal of clinical immunology” New treatments for immune disorders caused by FOXN1 deficiency are promising.
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January 2017 in “Orphanet journal of rare diseases” FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.
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March 2016 in “Autoimmunity reviews” Animal models have helped understand hair loss from alopecia areata and find new treatments.
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March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
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September 2019 in “Journal of Clinical Immunology” Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.