TLDR T cells with memory features grow in number and gather around hair follicles when there are not enough immune cells.
The study titled "Expanded T cells under lymphopenic condition exhibit memory phenotype and infiltrate around hair follicle" investigates the behavior of T cells in a lymphopenic environment. The findings reveal that these T cells adopt a memory phenotype and tend to infiltrate the area surrounding hair follicles. This suggests a potential link between immune cell behavior and hair follicle health, which could have implications for understanding conditions like alopecia.
33 citations,
September 2017 in “Journal of clinical immunology” New treatments for immune disorders caused by FOXN1 deficiency are promising.
32 citations,
January 2017 in “Orphanet journal of rare diseases” FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.
82 citations,
March 2016 in “Autoimmunity reviews” Animal models have helped understand hair loss from alopecia areata and find new treatments.
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40 citations,
March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
125 citations,
September 2019 in “Journal of Clinical Immunology” Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.
