HuR Ablation Destabilizes Foxp3 mRNA and Impairs Regulatory T Cell Function, Contributing to an Autoimmune Phenotype

    September 2025 in “ Frontiers in Immunology
    Fatemeh Fattahi, Jason S. Ellis, Laura Vallance, Kristin Bahleda, Julia Holden, Sarah Socha, Joshua Meier, Francisco Gomez‐Rivera, Ulus Atasoy
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    Studysummary In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.
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