HuR Ablation Destabilizes Foxp3 mRNA and Impairs Regulatory T Cell Function, Contributing to an Autoimmune Phenotype
September 2025
in “
Frontiers in Immunology
”
Studysummary In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.
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