Establishment and Functional Characterization of Immortalized Rabbit Dermal Papilla Cell Lines

April 2022 in “ Research Square (Research Square) ”

Jiali Li, Bohao Zhao, Chen Zhang, Xiyu Zhang, Yingying Dai, Shuaishuai Hu, Naisu Yang, Yang Chen, Xinsheng Wu

dermal papilla cells SV40 large T antigen hair follicle growth immortalized cell lines

TLDR Researchers created a stable rabbit cell line for hair research that doesn't age quickly or become cancerous.

In this study, researchers successfully established seven immortalized rabbit dermal papilla cell lines using the SV40 large T antigen, with a focus on overcoming the limitations of primary DPCs, such as low proliferative activity and rapid aging. Among these, the R-7 cell line was notable for its ability to survive beyond 50 passages without undergoing malignant transformation, maintaining the basic characteristics of primary DPCs. The R-7 line expressed key DPC markers and showed potential for future hair research, providing a theoretical basis for studying hair follicle growth and development.

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4 / 4 results

Establishment and Functional Characterization of Immortalized Rabbit Dermal Papilla Cell Lines

Research cited in this study

research Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine

research Establishment of an Immortalized Mouse Dermal Papilla Cell Strain with Optimized Culture Strategy

research Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

research The Establishment and Characterization of Immortalized Human Dermal Papilla Cells and Their Hair Growth Promoting Effects

research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

research Molecular Mechanisms Regulating Hair Follicle Development

research The Biology of Hair Follicles

research The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness

research The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles

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