December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review reports that anti-androgens, often combined with contraception, are supported for managing PCOS symptoms related to high androgen levels, but uncertainties remain about long-term safety and metabolic effects, indicating a need for future research on various treatment approaches.
January 1983 in “Journal of the Japan Veterinary Medical Association” This case study of a toy poodle with Cushing syndrome found that after unsuccessful initial treatments, hair growth and symptom alleviation occurred following daily administration of o,p'-DDD, despite initial side effects.
8 citations
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November 2024 in “Journal of Neuroendocrinology” This review discusses the role of gut steroids in communicating with the gut microbiota and their potential implications in treating gastrointestinal disorders and related brain conditions, suggesting new perspectives on steroid molecules as therapeutic agents.
February 2026 in “iScience” This study found distinct hair metal profiles in Parkinson's disease patients, with lower iron and copper, higher manganese and arsenic, and explored their link to gut dysfunction and microbiota dysbiosis, suggesting hair metal analysis as a promising diagnostic tool.
42 citations
,
February 1985 in “Journal of the American Academy of Dermatology” This study reports that once neoplastic causes are excluded, functional hirsutism can be effectively treated with low-dose dexamethasone, oral contraceptives, and spironolactone.
35 citations
,
February 2023 in “Biomolecules” This review explores the role of Granzyme B in autoimmune skin diseases and highlights its potential as a therapeutic target due to its involvement in impaired barrier function and inflammation.
July 2024 in “Journal of Investigative Dermatology” Machine learning can use blood tests to help predict moderate-to-severe alopecia areata.
August 2023 in “Journal of Periodontal Research” This study found a significant association between androgenic alopecia and periodontal disease in men aged 25–44, suggesting the relationship may begin early in adulthood.
February 2019 in “Americanae (AECID Library)” This study describes cases of diffuse alopecia and thyroid alterations in sheep, linking selenium and zinc deficiencies to decreased serum T3 and T4 concentrations and related skin conditions.
9 citations
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July 2011 in “Cytokine” This study suggests that finasteride treatment may improve pulmonary immune response in mice following trauma and sepsis, indicating potential as a therapeutic option after major trauma.
December 2025 in “Experimental Dermatology” This study found that uric acid-linked microvascular dysfunction may play a role in alopecia areata, suggesting that targeting endothelial function and uric acid regulation could be a potential management strategy.
6 citations
,
September 2018 in “International Journal of Molecular Sciences” This study found that intramuscular injections of a PRP-derivative in healthy beagle dogs did not result in statistically significant changes in lumbar muscle tissue or IGF-1 blood concentration, suggesting the treatment may be safe at therapeutic doses.
48 citations
,
April 2021 in “Journal of the American Academy of Dermatology” This study found that topical corticosteroids are the most supported first-line treatment for pediatric alopecia areata, with contact immunotherapy as the next best option.
15 citations
,
June 1995 in “The American Journal of the Medical Sciences” This study describes a case where finasteride treatment for benign prostatic hypertrophy was associated with gynecomastia in a 62-year-old man, which resolved after the drug was discontinued.
14 citations
,
June 2016 in “PubMed” This study found that patients with vitiligo commonly had facial involvement and associated autoimmune thyroid disease, highlighting the importance of monitoring thyroid antibodies and regular follow-up.
2 citations
,
August 1987 in “Australasian Journal of Dermatology” This review discusses skin diseases related to contraceptive use, reporting potential issues with oral contraceptives and infrequent reactions to mechanical or barrier methods without new clinical findings.
1 citations
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May 2012 in “Clinical and Experimental Dermatology” This article discusses the presence of iron in segmented heterochromia of scalp hair and concludes that it occurs without iron-deficiency anemia, reporting no new clinical results.
September 2004 in “Kitasato medical journal” This study found that a high dose of epidermal growth factor induced hair loss in sheep by causing apoptosis in anagen hair and transitioning the hair cycle to catagen.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” In this observational study, researchers found that 55% of participants with hair loss known as Khalitya had serum calcium deficiency, which aligns with both Ayurvedic and modern perspectives linking poor nutrition to hair disorder, highlighting the importance of dietary regulation and stress management.
April 2018 in “Journal of Investigative Dermatology” This study found that both Th1 and Th2 cytokine markers were elevated in the serum and skin of patients with alopecia areata, with Th2 markers more closely linked to disease severity.
102 citations
,
January 2010 in “Mediators of Inflammation” This paper discusses potential links between fat distribution, adipocyte dysfunction, and inflammatory markers in PCOS patients, without presenting new clinical data.
77 citations
,
March 2021 in “Nature” In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
37 citations
,
September 2002 in “Acta pædiatrica” In this study, a patient with cystic fibrosis developed iatrogenic Cushing's syndrome due to impaired clearance of budesonide from concurrent itraconazole use, highlighting the need for regular monitoring in such combination therapies.
6 citations
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September 2002 in “Acta pædiatrica” This case study observed that long-term itraconazole and budesonide use in a cystic fibrosis patient led to iatrogenic Cushing's syndrome due to inhibited metabolic clearance of budesonide, suggesting a need for regular adrenal insufficiency monitoring in such treatments.
75 citations
,
February 2016 in “The Journal of Sexual Medicine” This review highlights the efficacy of transdermal testosterone therapy in improving sexual function in women with hypoactive sexual desire disorder, though approved formulations and long-term safety data are limited.
33 citations
,
February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that overexpression of IGF-1 in transgenic mice stimulated increased vibrissa growth during the first neonatal hair cycle compared to their nontransgenic littermates.
45 citations
,
March 2010 in “Journal der Deutschen Dermatologischen Gesellschaft” This article discusses methods for diagnosing and managing diffuse hair loss and reports no new results; the authors emphasize systematic evaluation and the importance of psychological support.
21 citations
,
May 2005 in “Journal of the American Veterinary Medical Association” The exact cause of growth hormone-responsive alopecia in dogs is unclear.
18 citations
,
April 2021 in “Experimental Dermatology” This study in Italy observed telogen effluvium and trichodynia as common hair-related complications following COVID-19 infection, raising questions about underlying hair follicle biology and potential receptor involvement.
18 citations
,
August 2012 in “Clinical and Experimental Dermatology” This study concluded that a 3% IGF-1 liposomal gel improved hair thickness and growth in hamsters without inducing significant hepatotoxicity or myelotoxicity, suggesting its potential as a safe hair-loss treatment.