Epidermal Growth Factor Induced Apoptosis in the Outer Root Sheath Cells of Anagen Hair and Changed the Hair Cycle to the Catagen Phase

September 2004 in “ Kitasato medical journal ”

Akira Mukuno, Hiromi Tsuboi, Takao Fujimura, Kensei Katsuoka

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epidermal growth factor EGF anagen phase catagen phase apoptosis outer root sheath cells

Studysummary This study found that a high dose of epidermal growth factor induced hair loss in sheep by causing apoptosis in anagen hair and transitioning the hair cycle to catagen. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of epidermal growth factor (EGF) on anagen hair using sheep as a model. A single high-dose subcutaneous administration of EGF led to systemic hair loss, with the anagen phase transitioning to catagen. Six hours post-administration, serum EGF levels halved, and EGF was localized midway on the hair strand. Apoptosis occurred in the outer root sheath cells, and hair loss was observed 6 days later. The study concluded that EGF induced apoptosis in anagen hair, altering the hair cycle to the catagen phase.

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