Epidermal Growth Factor Induced Apoptosis in the Outer Root Sheath Cells of Anagen Hair and Changed the Hair Cycle to the Catagen Phase

September 2004 in “ Kitasato medical journal ”

Akira Mukuno, Hiromi Tsuboi, Takao Fujimura, Kensei Katsuoka

epidermal growth factor EGF anagen phase catagen phase apoptosis outer root sheath cells

TLDR Epidermal growth factor causes hair loss by triggering cell death and changing the hair cycle.

The study investigated the effects of epidermal growth factor (EGF) on anagen hair using sheep as a model. A single high-dose subcutaneous administration of EGF led to systemic hair loss, with the anagen phase transitioning to catagen. Six hours post-administration, serum EGF levels halved, and EGF was localized midway on the hair strand. Apoptosis occurred in the outer root sheath cells, and hair loss was observed 6 days later. The study concluded that EGF induced apoptosis in anagen hair, altering the hair cycle to the catagen phase.

View this study on ci.nii.ac.jp →

Discuss this study in the Community →

Related Community Posts Join

6 / 81 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Do you keep gains if you stop microneedling?

in Microneedling 15 upvotes 4 months ago

Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

community The end of balding: We may have just found the secret to hair regrowth

in Technology 676 upvotes 8 months ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 677 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Clearing the air on how non-surgical treatments really work

19 upvotes 6 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

Related Research

14 / 14 results

research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

30 citations , February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

research Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair

30 citations , October 2014 in “Experimental Dermatology”

Leptin from skin fat can slow hair growth during certain phases.

research Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice

6 citations , November 2013 in “International Journal of Radiation Biology”

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

research Pretreatment of Epidermal Growth Factor Promotes Primary Hair Recovery via the Dystrophic Anagen Pathway After Chemotherapy-Induced Alopecia

25 citations , May 2013 in “Experimental Dermatology”

Epidermal growth factor helps hair recover after chemotherapy.

6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

research Effects of Substance P on the Expression of Various Factors to Control Hair Growth in Human Hair Follicle Culture

1 citations , January 2004 in “Linchuang pifuke zazhi”

Substance P helps hair growth by extending the growth phase and affecting certain growth factors.

Epidermal Growth Factor Induced Apoptosis in the Outer Root Sheath Cells of Anagen Hair and Changed the Hair Cycle to the Catagen Phase

Related Community Posts Join

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Do you keep gains if you stop microneedling?

community The end of balding: We may have just found the secret to hair regrowth

community The Real Cause Of Androgenetic Alopecia

community Clearing the air on how non-surgical treatments really work

community New and Interesting HairLoss Studies/Papers/Reviews

Related Research

research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

research Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair

research Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice

research Pretreatment of Epidermal Growth Factor Promotes Primary Hair Recovery via the Dystrophic Anagen Pathway After Chemotherapy-Induced Alopecia

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

research Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen

research Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

research Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)

research Apoptosis Coordinates With Proliferation And Differentiation During Human Hair Follicle Morphogenesis

research Effects of Substance P on the Expression of Various Factors to Control Hair Growth in Human Hair Follicle Culture

research Biological Actions of Oligomeric Procyanidins: Proliferation of Epithelial Cells and Hair Follicle Growth

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro

research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?