Cushing's Syndrome Due to Pharmacological Interaction in a Cystic Fibrosis Patient
September 2002
in “
Acta pædiatrica
”
Cushing's syndrome iatrogenic itraconazole budesonide striae moon-face increased facial hair mood swings headaches weight gain irregular menstruation increased insulin requirement plasma cortisol adrenocorticotropin cytochrome P450 enzymes CYP3A isoforms adrenal suppression adrenal insufficiency Cushing's syndrome moon-face increased facial hair mood swings headaches weight gain irregular menstruation increased insulin requirement adrenal suppression adrenal insufficiency
Studysummary This case study observed that long-term itraconazole and budesonide use in a cystic fibrosis patient led to iatrogenic Cushing's syndrome due to inhibited metabolic clearance of budesonide, suggesting a need for regular adrenal insufficiency monitoring in such treatments.
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