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This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.

This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

This review discusses the negative effects of cigarette smoking on various skin conditions and emphasizes the importance of dermatologists advising patients to quit smoking, but it presents no new research findings.

Spironolactone in anti-acne cream can cause allergic skin reactions in some people.

This study found that Plakophilin 1 regulates innate immune responses in keratinocytes by controlling RNA helicase activity, balancing inflammation during epidermal immune challenges.

This abstract discusses alopecia areata, highlighting its complex autoimmune pathogenesis involving immune cells and signaling molecules, and underscores the importance of accurate diagnosis and tailored management strategies, noting the need for further research to improve treatments.

Environmental, chemical, mechanical, and personal health factors can all damage hair and contribute to hair loss or changes in hair quality.

This review discusses various nanoparticles used to enhance skin permeation and target delivery to skin organelles, but reports no new experimental results.

This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.

This review discusses various treatment options for adult female acne, highlighting the need for tailored approaches due to individual patient needs and reports no clinical outcomes.

This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.

This article discusses toxic epidermal necrolysis, highlighting its high mortality rate despite aggressive treatment, and notes controversy over using high-dose systemic corticosteroids as therapy.

This report describes an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after using low-potency hydrocortisone ointment extensively, highlighting caution with long-term topical treatments in such conditions.

This review details the diverse catalytic activities of abzymes in systemic lupus erythematosus (SLE) and reports no new experimental findings; it discusses the impact of these abzymes on disease pathogenesis.

This study found that certain lncRNA gene polymorphisms in HOTAIR and MALAT1 are associated with increased susceptibility to systemic lupus erythematosus, potentially informing clinical applications.

This report describes a case of acquired yellow hair discoloration in a 77-year-old woman, potentially caused by applying selenium sulfide after bacitracin zinc to her scalp.

This case report describes a rare instance where a young woman initially presented with macrophage activation syndrome as the first sign of systemic lupus erythematosus, and ultimately experienced multiorgan failure and death.

Targeted therapies for lung cancer are effective but require careful management of side effects to benefit patients.

This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.

The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.

This review discusses the advancements needed for gene therapy to become commonly used in dermatology and reports no new clinical results.

This review discusses current treatment strategies for alopecia and highlights the potential of lipid-based nanoparticles to improve drug delivery to the scalp and hair follicles, noting their ability to enhance skin penetration and drug stability while outlining associated challenges and the need for further research.

This review explores how various skin cell types contribute to photoaging driven by UV radiation, detailing their interactions and molecular mechanisms like oxidative stress and ECM degradation, ultimately offering insights for future anti-photoaging strategies.

This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.

This review provides a comprehensive synthesis of skin aging research, highlighting the interplay of genetic and environmental factors, cellular mechanisms, and advances in diagnostic and therapeutic strategies, while also addressing current debates and future directions in the anti-aging field.

This source discusses ichthyosis, a disorder causing dry, scaly skin, by exploring its genetic causes, potential systemic associations, and treatments, and correlates modern medical insights with Unani medicine principles focused on humoral balance and holistic care.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

This case report describes a 27-year-old female with systemic lupus erythematosus who presented with chilblain lupus erythematosus and melanonychia striata, emphasizing the rarity of such presentations in SLE patients.

This study suggests that targeting the increased expression of SIX1 in systemic sclerosis may be a viable strategy for addressing dermal fibrosis.