Ichthyosis in Unani Medicine: A Comprehensive Review of Disorders of Cornification and Their Modern Dermatological Correlates

The article provides a comprehensive review of ichthyosis, a group of disorders characterized by dry, scaly skin due to impaired epidermal barrier function. It discusses the prevalence, classification, and causes of both inherited and acquired forms, linking genetic mutations to the condition's pathophysiology. Inherited ichthyoses are linked to gene mutations affecting epidermal protein and lipid synthesis, while acquired ichthyosis is associated with systemic conditions. The review correlates traditional Unani medical concepts, such as abnormal black bile and excessive dryness, with modern genetic and metabolic understandings. It also outlines contemporary dermatological and Unani treatment strategies, emphasizing detoxification, humoral balance, and holistic care, showcasing the relevance of Unani medicine in managing ichthyosis alongside modern medical practices.