Common Dermatologic Disorders in Down Syndrome: Systematic Review

    February 2022 in “ JMIR Dermatology
    Megan Lam, Justin D. Lu, Levi Elhadad, Cathryn Sibbald, Raed Alhusayen
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    Studysummary This systematic review indicates that patients with Down syndrome have an increased prevalence of various dermatologic disorders, especially infectious, inflammatory, autoimmune, and connective tissue conditions.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This systematic review identified an increased prevalence of various dermatologic disorders in patients with Down syndrome (DS), including atopic dermatitis, hidradenitis suppurativa, ichthyosis, psoriasis, alopecia areata, vitiligo, and onychomycosis. The study analyzed 40 observational studies and 99 case reports, highlighting the need for improved screening and management guidelines for these conditions in the DS population. The findings suggested that patients with DS could benefit from regular dermatologic screenings to enable earlier diagnosis and treatment of these common cutaneous disorders.
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