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This source reports on advances in stimulus-responsive nanoparticle-based PROTACs (nano-PROTACs), which aim to overcome existing challenges like poor cell permeability and systemic off-target effects by enabling controlled protein degradation through endogenous or exogenous stimuli, potentially enhancing therapeutic efficacy and reducing toxicity.

This study explored the molecular factors behind delayed wound healing in obesity, highlighting that systemic changes like inflammation and collagen deposition alterations contribute to sustained skin inflammation and reduced mechanical resistance.

This study found that the systemic wrinkled skin phenotype in Xiang pigs involves gene expression changes and genetic variations associated with oxidative stress and extracellular matrix components, resembling features seen in Shar-Pei dogs.

This review examines the role of autophagy, specifically macrophage, chaperone-mediated, and microphagy, in the progression of six skin diseases, including psoriasis and systemic lupus erythematosus, illustrating its significance in cellular homeostasis.

This review highlights the role of keratin mutations in epidermolysis bullosa simplex and the resulting chronic inflammation, but it presents no new experimental findings.

This study developed dissolving microneedles incorporating a new AR degrader for treating androgenetic alopecia, showing that a single application leads to superior hair regeneration compared to daily minoxidil, without systemic toxicity or androgen-related issues.

In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.

In this study, a novel compound named AH-001 demonstrated effective androgen receptor protein degradation, reducing hair loss progression in a mouse model of androgenetic alopecia, with minimal systemic exposure and side effects, suggesting potential for safer treatment.

This review outlines advances in topical PROTACs for localized protein degradation, focusing on AH-001 and GT20029 for skin conditions, but presents no new clinical trial results.

In this study, using a novel topical androgen receptor suppressor, fluridil, significantly increased the percentage of growing hairs in males with androgenetic alopecia without systemic absorption or adverse side effects.

This review suggests that topically applied peptides may offer a promising alternative for managing pain in chronic wounds, with additional potential benefits of anti-inflammatory and regenerative activities, but acknowledges the challenges of delivering these peptides across damaged skin barriers.

This study developed a polyherbal chocolate formulation aimed at managing PCOS and hormonal balance, finding that formulation F2 showed excellent organoleptic properties and stability, with future in vivo studies being suggested.

This historical review discusses the ancient Egyptians' advanced wound-healing techniques, including the use of honey and moldy bread, and reports no new clinical results.

This review discusses the role of phytochemical nanoparticles in cervical cancer therapy and reports no new clinical results; the authors highlight their potential advantages over conventional chemotherapy.

This article discusses the similarities between symptoms of systemic lupus erythematosus and the Ayurvedic condition pittaadhkiya vatarakta, and reports no new clinical results; the authors propose treating SLE with specific Panchkarma procedures.

This review indicates that many former FDA category D and X systemic dermatologic medications may negatively impact male fertility, with further research needed to assess potential teratogenic effects.

This study demonstrated that CD19-CAR T cell therapy may promote structural regeneration in the skin of systemic sclerosis patients, as evidenced by histological improvements and fibroblast population changes, suggesting its potential for tissue remodeling in fibrotic diseases.

This study found that all examined biomarkers and clinical features were elevated in systemic lupus erythematosus patients, particularly ANA and Anti-dsDNA autoantibodies, but no single biomarker was sensitive or specific enough for diagnosis.

This study suggests that epidermal turnover could be a regulated mechanism of iron excretion, with systemic iron levels influencing keratinocyte behavior and differentiation markers in the skin.

Terbinafine is the most effective medicine for fungal nail infections, especially for diabetics and those with weak immune systems.

This study found that a single topical application of calcipotriol ointment did not affect systemic calcium levels in patients with chronic plaque psoriasis.

This review discusses the dermatological and systemic adverse effects of hair dye use, particularly focusing on the common allergen para-phenylenediamine, and reports no new clinical data.

This study examined finasteride degradation under stress conditions, identifying three unique degradation products in acidic environments, providing insights into impurity profiling and quality control for finasteride formulations.

This review discusses how environmental factors like lifestyle, nutrition, and vitamin deficiencies may influence autoimmune diseases such as MS, SLE, and AA, highlighting associations with vitamin D levels and dietary interventions, but notes a lack of conclusive evidence for their roles in disease pathogenesis.

This review highlights the potential for physical exercise to reduce treatment toxicity and modification rates in patients with metastatic colorectal cancer receiving systemic treatments, suggesting benefits for survival outcomes; it recommends further trials to confirm these findings.

Olive leaf extract may help reduce aging signs in postmenopausal women.

This case report highlights a 17-year-old girl with overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus, emphasizing the critical importance of early diagnosis and intensive therapy including plasma exchange.

This study found that FGF5-/- rabbits exhibited a significant long hair phenotype by prolonging the anagen phase, suggesting FGF5 acts as a negative regulator of hair growth.

This case report describes the first recorded instance of posterior cerebral artery dissection in a patient with childhood-onset systemic lupus erythematosus, which uniquely progressed from cerebral infarction to subarachnoid hemorrhage.

This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.