The Systemic Wrinkled Skin Phenotype Involves Aberrant Expression and Variation of Genes Related to Oxidative Stress and Extracellular Matrix in Xiang Pigs

The study on Xiang pigs reveals that the wrinkled skin phenotype is linked to aberrant gene expression and genetic variations related to oxidative stress and the extracellular matrix (ECM). Researchers identified 699 differentially expressed genes (DEGs), with 272 downregulated and 427 upregulated, affecting pathways like reactive oxygen species (ROS) production and ECM signaling. Structural and copy number variations in 335 DEGs were found, suggesting a genetic basis for the phenotype. An F2 crossbreeding experiment indicated autosomal recessive inheritance, with 26% of offspring showing the phenotype. The study highlights the role of oxidative stress and ECM degradation in wrinkle formation, potentially informing future skin health therapies.