Facial Skin Aging: An Integrative Analysis of Genetics, Epigenetics, and Lifestyle Factors

December 2025 in “ GeroScience ”

Rezvan Noroozi, Aleksandra Pisarek-Pacek, B. Wysocka, Kamila Migacz-Gruszka, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Dagmara Lisman, Julia Zacharczuk, Joanna Rudnicka, Aleksandra Iljin, Kathryn C. Fitzgerald, Małgorzata Magdalena Michalczyk, Piotr Kaczka, Michał Krzysztofik, Maciej Kostrzewa, Aneta Sitek, Magdalena Spólnicka, Andrzej Ossowski, Wojciech Branicki, Ewelina Pośpiech

genetics epigenetics lifestyle factors facial skin aging EDAR NRG1 facial wrinkles environmental stressors epigenetic aging GrimAge clock FitAge clock SNP stress response adiposity methylation skin phenotypes

Studysummary This study found that both genetic and epigenetic factors significantly influence age-related facial skin aging, with lifestyle and environmental factors also playing a substantial role.

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