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research Anatomy and Function of the Skin
This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.
research Structure and Function of the Skin
This chapter discusses the structure and function of the skin, detailing its protective roles and the layers that comprise it, but reports no new research findings.
research Impact of One-Week Administration of Dihydrotestosterone in Rat Anterior Pituitary Gland
This study found that dihydrotestosterone treatment in female rats altered anterior pituitary gland gene expression, with significant repression of prolactin and inhibition of GnRH receptor gene expression, suggesting specific hormone production changes.
research Efficacy of Autologous Platelet-Rich Plasma alone or in Combination with a Lotion Containing Growth-Factor like Polypeptides and Taurine in the Treatment of Androgenic Alopecia: A Randomized, Prospective, AssessorBlinded Trial
In this study, a combination of GFM-lotion with autologous PRP treatment improved efficacy in treating androgenic alopecia compared to PRP alone, as shown by significant improvements in clinical assessments over 3 months.
research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies
This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.
research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles
In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.
research Tissue engineering; strategies, tissues, and biomaterials
This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.
research Intracrine androgen biosynthesis, metabolism and action revisited
This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.
research Targeting integrin pathways: mechanisms and advances in therapy
This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.
research Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review
This paper discusses strategies for creating sustainable cosmetic emulsions, highlighting the use of food waste, fermentation processes, and low-energy emulsification methods to minimize carbon footprint while preserving the bioactive properties of raw materials.
research Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights
This review discusses the potential of hydrogel-based interventions for radiation-induced skin injury, providing no new clinical results but highlighting their synergistic mechanisms and promise in improving treatment strategies.
research Quantification of the Vitamin D Receptor−Coregulator Interaction
This study found that both the natural ligand 1alpha,25(OH)(2)D(3) and the synthetic agonist LG190178 bind similarly to the vitamin D receptor's coregulator motifs, suggesting similar biological functions.
research Pharmacological Approaches to Controlling Cardiometabolic Risk in Women with PCOS
This review explores current and emerging treatments for polycystic ovary syndrome, focusing on managing hyperandrogenism and cardiometabolic risk, but reports no new clinical results.
research Vitamin A in Skin and Hair: An Update
This review discusses new research on the role of retinoids in skin and hair health and reports no clinical results.
research Combinatorial Biosynthesis of Sulfated Benzenediol Lactones with a Phenolic Sulfotransferase from Fusarium graminearum PH-1
This study identified a fungal sulfotransferase enzyme, FgSULT1, from *Fusarium graminearum*, expanding the sulfotransferase superfamily and offering new biocatalytic methods for producing bioactive sulfates.
research Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice
In a study on mice, cow placenta extract showed strong antioxidant activities and reduced collagen damage, suggesting it could help delay skin aging caused by D-galactose.
research Gene therapy to enhance angiogenesis in chronic wounds
This review discusses various gene therapy and non-viral delivery methods to promote angiogenesis for chronic wound healing, but it reports no new clinical results.
research p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen)
In this study, a synthetic antagonist of the p75 neurotrophin receptor was found to significantly inhibit hair follicle regression in murine skin cultures, suggesting a potential role in treating hair disorders characterized by premature catagen entry.
research Expression and tissue distribution analysis of Angiotensin II in sheep (Ovis aries) skins associated with white and black coat colors
This study found that Angiotensin II is expressed more in black sheep skins compared to white sheep skins, suggesting its involvement in coat color regulation.
research Effects of Minoxidil on Cultured Human Skin Fibroblasts
This review discusses the effects of minoxidil on human skin fibroblasts, reporting its potential to inhibit lysyl hydroxylase activity and DNA synthesis, suggesting it may have antifibrotic applications for collagen-related skin conditions.
research Oral delivery of marine shellfish supramolecule peptides for skin wound healing
This study found that oral administration of naturally safe active polypeptides from marine shellfish promoted scarless dermal wound healing in mice, potentially via effects on inflammation, fibroblast activity, and the "skin-gut" axis.
research Berberine-based strategies: novel delivery systems bring out new potential for wound healing
This review article summarized the design, synthesis, and application of innovative delivery systems for berberine, highlighting their potential to enhance wound healing through improved bioactivity and bioavailability, particularly in challenging conditions like diabetic and infected wounds.
research Chemotherapy of psoriasis and other skin disorders with oral retinoids
In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.
research Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts
Minoxidil reduces lysine hydroxylase in skin cells.
research Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications
This review discusses recent research and applications of RADA16 and RADA16-based peptide scaffolds in biomedicine, including their roles in tissue repair and drug delivery, but reports no new clinical results.
research Thymosin β4increases hair growth by activation of hair follicle stem cells
In this study, thymosin beta4 was found to stimulate hair growth in normal rats and mice by affecting key processes in the hair follicle cycle, such as stem cell migration and extracellular matrix remodeling.
research Lipid Nanoparticles Based Cosmetics with Potential Application in Alleviating Skin Disorders
This review discusses lipid nanoparticle-based cosmetics, emphasizing their potential in protecting skin from radiation and treating conditions like atopic dermatitis and psoriasis with synthetic and natural antioxidants. It highlights recent research on these formulations' effectiveness in alleviating skin disorders and enhancing skin health.
research Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes
In vitro, this study suggests that CRH may act as an autocrine hormone in human sebocytes, influencing lipid synthesis and potentially impacting skin disorders related to alterations in sebaceous lipid formation.
research 8 Hair follicles and associated glands as androgen targets
This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.