Berberine-Based Strategies: Novel Delivery Systems Bring Out New Potential for Wound Healing

The study developed a radially oriented poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber dressing patch using a modified electrospinning technique, which demonstrated improved mechanical properties, surface hydrophilicity, and biological functions compared to traditional randomly oriented patches. By incorporating berberine (Beri) into the nanofibers, the patch exhibited sustained drug release, anti-inflammatory properties, and enhanced cell proliferation while inhibiting bacterial growth. In animal studies, the high Beri content patch significantly accelerated diabetic wound healing in mice, achieving 100% wound closure in 18 days and improving healing quality through enhanced collagen deposition, re-epithelialization, neovascularization, and increased hair follicles. This innovative approach combines physical and biological cues for effective diabetic wound treatment.