Berberine-Based Strategies: Novel Delivery Systems Bring Out New Potential for Wound Healing
October 2025
in “
Chinese Medicine
”
Studysummary This review article summarized the design, synthesis, and application of innovative delivery systems for berberine, highlighting their potential to enhance wound healing through improved bioactivity and bioavailability, particularly in challenging conditions like diabetic and infected wounds. Our plain-language summary of this paper — not a Tressless recommendation.
Berberine (BBR)-based delivery systems show significant potential in enhancing wound healing, particularly for acute, diabetic, infected, and burned wounds. These systems, including hydrogels, nanoparticles, and nanofibers, improve BBR's bioavailability and therapeutic efficacy by providing controlled and sustained release, reducing oxidative stress and inflammation, and promoting cell proliferation and wound closure. They exhibit strong antibacterial properties against pathogens like S. aureus and E. coli, and are especially beneficial for diabetic wounds by promoting angiogenesis and tissue regeneration. Despite challenges such as stability and clinical validation, these advanced delivery systems offer promising prospects for clinical applications in wound management.
