Pharmacological Approaches to Controlling Cardiometabolic Risk in Women with PCOS

December 2020 in “ International Journal of Molecular Sciences ”

Andrea Cignarella, Roberto Mioni, Chiara Sabbadin, Francesca Dassie, Matteo Parolin, Roberto Vettor, Mattia Barbot, Carla Scaroni

androgen receptor antagonists 5α-reductase inhibitors synthetic progestogens metformin inositols combined oral contraceptives aldosterone antagonists hyperandrogenism insulin sensitivity birth control pills spironolactone finasteride inositol supplements oral contraceptives aldactone

TLDR Treatments for PCOS aim to reduce androgen levels and improve insulin sensitivity to lower cardiometabolic risk.

The review discussed various pharmacological approaches to managing cardiometabolic risk in women with PCOS, emphasizing the role of hyperandrogenism and insulin resistance. Treatments included antiandrogens like flutamide and spironolactone, which improved symptoms such as hirsutism and insulin resistance. Metformin and inositols were effective in improving insulin sensitivity and metabolic profiles. Combined oral contraceptives were used for androgen-related symptoms but carried risks like thromboembolic events. The review highlighted the importance of individualized treatment plans and lifestyle changes, noting the need for further research to optimize therapy and understand long-term effects.

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Research cited in this study

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