Expression and Tissue Distribution Analysis of Angiotensin II in Sheep Skins Associated with White and Black Coat Colors

The study found that Angiotensin II (AngII) was expressed at significantly higher levels in the skin of black sheep compared to white sheep. AngII was localized in the hair bulb and outer root sheath of hair follicles. These findings suggested that AngII played a role in coat color regulation in sheep, potentially influencing melanin synthesis by tyrosinase in melanocytes. The research provided a theoretical basis for further exploration of AngII signaling in coat color formation. The study involved skin samples from six healthy one-year-old female sheep, three black and three white.