TLDR Blocking a specific receptor slows down hair loss in mice.
The study explored the effect of a p75 neurotrophin receptor (p75NTR) antagonist on hair follicle regression in mice. The antagonist was designed to block neurotrophin binding to p75NTR, aiming to prevent apoptosis and delay the catagen phase of the hair cycle. Using murine skin organ culture, the results indicated that the antagonist significantly delayed catagen in C57BL/6 mice skin biopsies by 15.9±2.6% on day 17 and 33±4.1% on day 18 after hair removal. It also counteracted the catagen-inducing effects of neurotrophins. The study concluded that the p75NTR antagonist could be a potential treatment for hair loss disorders associated with premature catagen, such as telogen effluvium, androgenetic alopecia, and alopecia areata.
96 citations,
October 2000 in “The FASEB Journal” The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
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August 1994 in “Journal of Investigative Dermatology” Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.
96 citations,
October 2000 in “The FASEB Journal” The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.
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July 2004 in “American Journal of Pathology” Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.
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January 2012 in “Biological & Pharmaceutical Bulletin” Hura crepitans and its compound daphne factor F3 may help treat hair loss by blocking a specific hair growth inhibitor.
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March 2008 in “Molecular and Cellular Endocrinology” Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
2 citations,
January 2023 in “International journal of biological sciences” Gray hair can potentially be reversed, leading to new treatments.
