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GlossaryNeurotrophins

proteins that support neuron growth, survival, and function

Neurotrophins are a family of proteins that play a crucial role in the growth, survival, and maintenance of neurons, which are the cells responsible for transmitting information in the nervous system. They help support the health of nerve cells and are involved in processes like learning and memory. For professionals, key members of this family include nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).

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research Neurotrophins, Nociceptors, And Pain

189 citations, May 1999 in “Microscopy Research and Technique”

Neurotrophins, especially NGF, are crucial for pain development and management.

research Epithelial Growth Control by Neurotrophins: Leads and Lessons from the Hair Follicle

99 citations, January 2004 in “Progress in brain research”

Neurotrophins are important for hair growth and could help treat hair loss.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations, October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

research P75 Neurotrophin Receptor Antagonist Retards Apoptosis-Driven Hair Follicle Involution (Catagen)

24 citations, January 2003 in “Journal of Investigative Dermatology”

Blocking a specific receptor slows down hair loss in mice.

research Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons

11 citations, December 2011 in “Biochemical journal”

Neurotrophin-4 increases calcium current in specific mouse neurons through the PI3K pathway.

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community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 1 year ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.