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360-390 / 1000+ resultsresearch Three-dimensional analyses of touch domes in the hairy skin of the cat paw reveal morphological substrates for complex sensory processing
This study revealed the complex three-dimensional innervation of touch domes in cat forepaw skin, highlighting the extensive branching and unmyelinated endings associated with Merkel cell–axon complexes.
research The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
This study found that quercitrin, a natural compound, enhances Wnt/β-catenin signaling and may help mitigate synapse loss and memory impairment in Alzheimer's models.
research Hyperinnervation inhibits organ-level regeneration in mammalian skin
This study found that late embryonic skin injuries can regenerate multiple tissue types, but this ability is hindered postnatally due to fibroblast-driven hyperinnervation, which can be mitigated to enable regeneration.
research Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease
In this review, the researchers reported that 5α-reductase inhibitors demonstrated neuroprotective effects and reduced dyskinesias in animal models of Parkinson's disease, suggesting their potential for repurposing to manage symptoms in men with PD.
research Hair Zinc and Chromium Levels Were Associated with a Reduced Likelihood of Age Related Cognitive Decline in Centenarians and Oldest-Old Adults
In this study, hair levels of zinc and chromium were associated with a reduced likelihood of age-related cognitive decline in centenarians and oldest-old adults, suggesting further research is needed on these elements' potential role in cognitive health among the elderly.
research Mesenchymal Stem Cells for Regenerative Medicine
This article provides an overview of mesenchymal stem cells, highlighting their extraction methods, differentiation potential, and applications in regenerative medicine, but reports no new clinical findings.
research Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs)
This review discusses the therapeutic potential of adipose-derived stem cells compared to other mesenchymal stem cells, emphasizing their promise in treating neurodegenerative, cardiovascular, and autoimmune diseases, but reports no new clinical results.
research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.
research The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
This review discusses how dehydroepiandrosterone (DHEA) may exert its biological effects through multiple receptors and reports no new clinical results.
research Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility
This review discusses how research on keratin biology has enhanced the understanding of epidermolysis bullosa simplex and indicates potential new therapeutic approaches, but it presents no new experimental results.
research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin
This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.
research Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications
This review discusses the antioxidant activity of natural polysaccharides, highlighting their potential applications in areas like drug delivery and tissue engineering, but reports no new experimental findings.
research Extracellular Vesicles in Skin Wound Healing
This review discusses the role of extracellular vesicles in wound healing and explores their potential applications in skin repair and treatment of dermal diseases, reporting no new clinical findings.
research Targeting of Smoothened for therapeutic gain
This review discusses the therapeutic potential of Smoothened modulators for cancer treatment and explores their pharmacological implications, but reports no new clinical findings.
research Fluorescence Microscopy—An Outline of Hardware, Biological Handling, and Fluorophore Considerations
This review outlines key considerations for designing fluorescence microscopy experiments in cell biology, discussing the importance of hardware availability, suitability of biological models, and imaging agents to achieve high-resolution and informative images.
research Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea
This study observed that after hair cell loss in the mouse cochlea, supporting cells were replaced by migrating non-specialised cells, with genetic background affecting the rate of tissue re-organization.
research The Potential of Ginkgo biloba as a Source of Biologically Active Compounds—A Review of the Recent Literature and Patents
This source reviews recent research on Ginkgo biloba, highlighting its medicinal benefits due to compounds in the leaves and concerns over toxic alkylphenols in seeds. It also discusses patents for its food production uses and ongoing studies on toxicity and drug interactions.
research 3α-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats
This study found that 3alpha-diol, an androgen metabolite, improved cognitive and affective performance in aged male rats, suggesting its role in countering age-related decline in hippocampally-influenced behaviors.
research GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
This review discusses the roles and therapeutic effects of GLP-1 receptor agonists on the nervous, cardiovascular, and endocrine systems, but reports no new clinical results, emphasizing the need for further research on their impact on metabolism and tumor relationships in type 2 diabetes patients.
research Medicinal Chemistry of Drugs with N-Oxide Functionalities
This article summarizes the properties, synthesis, and biomedical applications of molecules with N-oxide functionalities, emphasizing their growing role in healthcare due to their unique properties, such as water solubility and redox reactivity, crucial for drug targeting and cytotoxicity.
research Targeting integrin pathways: mechanisms and advances in therapy
This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.
research LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure
This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.
research Immune-Epithelial Cross Talk in Regeneration and Repair
This review discusses how immune mechanisms contribute to the regeneration and repair of epithelial tissues and highlights their potential role in both disease and therapeutic innovation; it reports no new clinical results.
research Engineered extracellular vesicles for tissue repair and regeneration
This review summarizes the therapeutic potential and development of engineered extracellular vesicles for tissue repair and regenerative medicine, reporting no new clinical findings.
research Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex
This study identified genetic, biological, and technical factors that influence circRNA expression in the human brain, connecting these factors to potential genetic risk for diseases like schizophrenia and type II diabetes.
research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
This study found that MDSC exosomes promoted partial hair regrowth and modulated immune responses in mice with alopecia areata, suggesting potential as a treatment for autoimmune diseases.
research Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments
This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.
research Direct Vasodilators and Sympatholytic Agents
This article discusses the use of direct vasodilators and sympatholytic agents in hypertension management, highlighting their utility in specific cases like refractory hypertension and heart failure, but reports no new clinical results.
research Modulating the Antioxidant Response for Better Oxidative Stress-Inducing Therapies: How to Take Advantage of Two Sides of the Same Medal?
This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.