81 citations
,
February 2016 in “Veterinary pathology” This review discusses the commonly observed pathological findings in progeroid mouse models and highlights the importance of understanding mouse strain backgrounds and progeria-related phenotypes for accurate pathology data interpretation.
79 citations
,
February 2009 in “Human Genetics” 75 citations
,
July 2016 in “New phytologist” This study found that RSL4 in Arabidopsis thaliana regulates genes necessary for root hair elongation by controlling proteins involved in cell signaling, cell wall modification, and secretion.
70 citations
,
June 2023 in “International Journal of Molecular Sciences” In this review, researchers explored how air pollutants increase oxidative stress and inflammation in human skin, affect vitamin D synthesis, and interact with the skin microbiota, also discussing AhR/Nrf2 as a potential target for treating pollution-related skin conditions.
63 citations
,
September 2020 in “Frontiers in Microbiology” This review discusses the potential health benefits of probiotics as a "Bio-Therapy" in food and medicine, noting that more research is needed to fully understand their mechanisms and effectiveness.
56 citations
,
March 2017 in “Plant and Cell Physiology” This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.
55 citations
,
April 2022 in “Frontiers in Immunology” This review examines the role of cholesterol metabolism in coronavirus infections, discussing its potential as a target for antiviral strategies and a marker for monitoring infection status, but presents no new results.
55 citations
,
October 2020 in “Frontiers in Pharmacology” This review discusses the role of endolysosomes in SARS-CoV-2 infection and COVID-19 pathogenesis, and explores potential therapeutic strategies targeting these cellular structures, but reports no new clinical findings.
52 citations
,
January 2021 in “Journal of Thoracic Oncology” Effective vaccines and treatments are crucial for long-term COVID-19 control.
51 citations
,
September 2000 in “Acta dermato-venereologica” This study found that PPAR alpha, -delta, and -gamma are expressed in human hair follicle cells, and clofibrate exhibited a beneficial effect on hair follicle survival in culture within a specific concentration range.
47 citations
,
September 2022 in “European Heart Journal” This consensus document reviews current knowledge on sex differences in essential hypertension and identifies areas needing further research to improve sex-specific prevention and management strategies.
46 citations
,
April 2014 in “PLOS ONE” This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.
41 citations
,
February 2021 in “Cureus” This study found that in males with mild COVID-19, treatment with dutasteride, along with standard therapy, may reduce viral shedding and inflammation compared to placebo.
38 citations
,
December 2006 in “Journal of Investigative Dermatology” Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.
35 citations
,
May 2008 in “Drug and Alcohol Dependence” Female mice are less affected by certain substances that alter alcohol consumption compared to male mice.
33 citations
,
December 2015 in “International Journal of Molecular Sciences” This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.
33 citations
,
January 2001 in “Critical care clinics” This article reviews the roles and synthesis of essential long-chain fatty acids in the body and reports no new research findings; it emphasizes the importance of dietary sources for these lipids.
31 citations
,
November 2015 in “PloS one” In this study, modulating Tyrosinase expression altered mouse coat color by affecting melanosome accumulation, indicating that melanosome maturity plays a role in determining skin and hair color beyond total melanin content.
31 citations
,
April 2004 in “Journal of Investigative Dermatology” This study found that a newly identified gene, mK17n, may explain the lack of nail issues in mK17 null mice by compensating for mK17's function in the nail bed.
29 citations
,
March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
29 citations
,
February 2022 in “Frontiers in Cell and Developmental Biology” This review discusses strategies to improve CRISPR/Cas systems by addressing limitations like off-target effects and delivery inefficiencies, offering practical guidance and highlighting future applications, but reports no new research findings.
29 citations
,
December 2021 in “Biomedicines” This study found that exosomes from different mesenchymal stem cell sources had distinct effects on immune cell functions and varied microRNA expression profiles compared to their original cells.
29 citations
,
April 2020 in “Biomolecules” This review discusses the potential biomedical and clinical applications of brassinosteroids, highlighting their observed antiviral, anticancerous, and other bioactivities in animal test systems, but reports no new findings.
25 citations
,
April 2021 in “The EMBO Journal” This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.
25 citations
,
January 2012 in “Proteome Science” This study suggests that common proteomic changes, including the expression of the protein S100A6, may occur during the expansion of AD-MSC from different donors.
22 citations
,
January 2012 in “Mediators of inflammation” This review discusses the potential benefits of nonantibiotic macrolides for treating inflammatory skin disorders and reports no new clinical results.
20 citations
,
February 2023 in “Biology” This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.
18 citations
,
October 2013 in “Stem Cell Research & Therapy” This study found that combining polybrene and a ROCK inhibitor can effectively expand human keratinocyte stem/progenitor cells carrying a transgene, aiding their use in regenerative medicine.
16 citations
,
March 2023 in “Gels” This study found that paeonol-loaded liposomal gels demonstrated antioxidant effects and relieved inflammation in AD-like mice, suggesting potential benefits for treating atopic dermatitis.
15 citations
,
November 2020 in “Development” This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.