September 2023 in “Biomedicines” In this study, researchers found that subjects with clinical alopecia had significantly higher levels of squalene in their hair bulbs compared to controls, suggesting squalene as a potential metabolic and pathogenic marker for certain alopecia conditions.
561 citations
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April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
April 2025 in “International Journal of Molecular Sciences” In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.
This study found that chronic UVR exposure in mice and humans leads to a permanent loss of papillary fibroblasts in the upper dermis, which is associated with changes in the extracellular matrix.
3 citations
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October 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the epidemiology, risk factors, clinical features, and management of scalp melanomas, highlighting their high mortality rates and specific challenges in diagnosis and treatment; it reports no new research findings.
142 citations
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February 2016 in “Science” This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.
81 citations
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December 2007 in “Acta materialia” This study conducted in situ tensile loading experiments with atomic force microscopy to observe how conditioning treatments affect the tensile response of virgin, chemically damaged, and mechanically damaged Caucasian hair.
79 citations
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December 2017 in “Cosmetics” This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.
44 citations
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November 2012 in “International journal of nanomedicine” This study found that silicone oil-in-water nanoemulsions using nonionic surfactants can enhance silicone oil absorption on hair, suggesting a promising method for hair care applications.
14 citations
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March 2014 in “Experimental and Molecular Pathology” This study found that sulfur mustard affects hair follicles and sebaceous glands in the skin by causing cellular damage, inflammation, and disrupting wound healing processes in hairless mice.
9 citations
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April 2021 in “Frontiers in Immunology” This review discusses the role and mechanisms of unconventional lymphocytes in promoting tissue repair and maintaining mucosal barrier integrity in the skin, gut, and lungs, but reports no new findings.
7 citations
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November 2006 in “Journal of immunological methods” This study found that the novel dot-block method can effectively measure early- and advanced-glycation products in hair, suggesting its potential for monitoring diabetes progression and other chronic conditions.
1 citations
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July 2021 in “IntechOpen eBooks” This review discusses unspecific factors involved in the pathogenesis of skin diseases and potential ways cytokeratin changes might alleviate these conditions, but reports no new clinical results.
December 2024 in “Cell Communication and Signaling” This study found that subcutaneous adipose tissue-derived extracellular vesicles (AT-EVs) protect skin from photodamage by enhancing fibroblast proliferation and reducing oxidative stress compared to those from adipose-derived stem cells.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers found that SPF50+ sunscreens provided the highest DNA protection against solar-simulated radiation in a reconstituted human epidermis model, with formulation type not affecting efficacy for a given SPF.
September 2017 in “Journal of Investigative Dermatology” Loss of COL17A1 causes hair follicle stem cells to age and leads to hair loss.
December 2025 in “Applied Sciences” This study examined argan oil inclusion complexes with β-CD, finding that these complexes improve the antibacterial efficacy, uniformity, and mechanical performance of hair treatment formulations while enhancing the durability of bleached hair, suggesting their potential as stable and effective cosmetic ingredients.
July 2021 in “CRC Press eBooks” This study reports that topical finasteride significantly reduced scalp and plasma dihydrotestosterone in men and women without altering serum testosterone levels, with promising preliminary results.
53 citations
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July 2016 in “Cosmetics” This study reviews the biology and cosmetic treatment of hair, emphasizing future advancements in safer, more effective procedures to meet consumer needs for hair care.
August 2024 in “Cosmetics” In this study, a bleaching protocol was developed to evaluate hair repair products, revealing that K18® and Olaplex® improve hair brightness and lightness, with distinct impacts on hair fiber properties.
61 citations
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January 2011 in “PloS one” In this study, researchers found that Notch signaling is crucial for late-stage epidermal differentiation and postnatal hair cycle homeostasis by regulating hair follicle stem cell proliferation and differentiation.
51 citations
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January 2014 in “International journal of trichology” This review examines the pH levels of various shampoos and reports no new clinical results, highlighting the potential importance of labeling pH values on shampoo packaging for hair and scalp health.
33 citations
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April 2020 in “Journal of Clinical Investigation” This study found that hair follicle stem cells from hidradenitis suppurativa patients showed alterations in cell cycle regulation and DNA replication, potentially linking genetic predisposition to the skin inflammation characteristic of the disease.
32 citations
,
January 2022 in “International Journal of Molecular Sciences” This review discusses the impact of melatonin and its metabolites on skin aging, summarizing how they may serve as "aging neutralizers" through their anti-oxidative and anti-inflammatory properties, but reports no new clinical results.
14 citations
,
August 2013 in “Journal of Parasitology” This study reported that 39.7% of Amargosa voles had mite-associated lesions, which may severely impact their health and fitness.
11 citations
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January 2023 in “BioMed Research International” This review discusses the use of microbial biosurfactants as a safer alternative to chemical surfactants in cosmetics due to their antibacterial, moisturizing, and low toxicity properties, but it reports no new clinical findings.
10 citations
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June 2019 in “International Journal of Pharmaceutics” Hair removal methods damage the skin barrier and affect substance penetration.
4 citations
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February 2023 in “Frontiers in Oncology” In this study, Nano-Pulse Stimulation Therapy successfully cleared up to 91% of melanoma tumors in mice with less skin damage compared to cryoablation, which cleared up to 66% of tumors.
4 citations
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November 2022 in “Nutrients” In a study on mice, cow placenta extract showed strong antioxidant activities and reduced collagen damage, suggesting it could help delay skin aging caused by D-galactose.
3 citations
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July 2023 in “Acta Biomaterialia” This study demonstrates that a bioinspired peptide, PepACS, can efficiently and safely perm hair by interacting with keratin's sulfhydryl group without compromising tensile strength, and it shows potential for hair repair and dyeing applications in the hair care industry.