Evaluation of the Influence of Sunscreen Formulations and SPF on Genoprotection in a Hair Follicle-Derived Human Epidermis Model

    September 2017 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Daniel Bacqueville, Thierry Douki, L. Duprat, B. Guiraud, H. Dromigny, V. Perier, S. Bessou‐Touya, Hélène Duplan
    Studysummary The researchers found that SPF50+ sunscreens provided the highest DNA protection against solar-simulated radiation in a reconstituted human epidermis model, with formulation type not affecting efficacy for a given SPF. Our plain-language summary of this paper — not a Tressless recommendation.
    The study evaluated the genoprotective effects of various sunscreen formulations (sprays, lotions, creams, and emulsions) with different Sun Protection Factors (SPF20, 30, and 50+) using a reconstituted human epidermis model derived from hair follicles. DNA damage was assessed by quantifying bipyrimidine photoproducts after solar-simulated radiation exposure. Results indicated that higher SPF values corresponded to greater DNA protection, with SPF50+ providing the most effective photoprotection. The type of sunscreen formulation did not significantly impact the level of DNA protection for the same SPF, demonstrating that sunscreens are effective in protecting against solar radiation regardless of their form.
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