Nano-Pulse Stimulation Therapy Is Superior to Cryoablation in Clearing Murine Melanoma Tumors

February 2023 in “ Frontiers in Oncology ”

Amanda McDaniel, Bruce Freimark, Cebrina Navarro, Kristin Von Rothstein, Dacia Gonzalez, Keith E. Linder, Richard Nuccitelli

Nano-Pulse Stimulation NPS cryoablation melanoma tumor skin damage dermal fibrosis muscle atrophy hair follicle loss cryotherapy

TLDR Nano-Pulse Stimulation™ Therapy is more effective and less damaging than cryoablation for treating melanoma tumors in mice.

The study demonstrates that Nano-Pulse Stimulation™ (NPS™) therapy is more effective than cryoablation in clearing B16-F10 murine melanoma tumors, achieving a 96% tumor clearance rate at a high dose compared to 66% for high-dose cryoablation. NPS-treated tumors did not recur, while cryoablation-treated tumors often regrew within 20-30 days. NPS caused less dermal fibrosis and tissue damage, and the survival rate was significantly higher in the high-dose NPS group (91%) compared to the low-dose cryo group (58%). NPS also induced an immune response, suggesting its potential for treating human skin lesions with fewer side effects.

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