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This study demonstrated that finasteride-loaded PLGA microspheres created using a novel microfluidic device exhibit extended drug release in beagle dogs, with modifications allowing for release up to 3 months.

In this study, penetration of FA-PLGA nanoparticles into hair follicles was observed in excised dog, rat, and porcine skin, with the deepest penetration in porcine skin, suggesting its similarity to human skin for drug delivery studies.

This study described a novel three-dimensional-printed microneedle system designed for improved transdermal delivery of minoxidil to treat hair loss, demonstrating effective hair regrowth and safety in a mouse model while allowing sustainable needle base recovery.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.

This study demonstrated that a light-activated RNAi approach using hollow gold nanoshells effectively targets human prostate cancer cells with reduced off-target toxicity and material use compared to standard methods.

This study found that pen-type microwells enhanced hair follicle germ formation by promoting cell assembly, suggesting microwell array geometry significantly influences in vitro hair follicle development.

This study demonstrated that combining amorphization and nanonization of drugs enhances both saturation solubility and dissolution rate, potentially offering therapeutic benefits for formulations like dermal applications.

This review explores the formulation, characterization, and applications of microemulsions, highlighting their potential for enhanced cutaneous drug delivery by improving bioavailability and enabling sustained release of both hydrophilic and hydrophobic drugs.

This study suggests that finasteride-loaded polyvinyl alcohol/chitosan microspheres could be a promising embolic agent for benign prostatic hyperplasia, showing effective occlusion and sustained drug release in preclinical models.

This study found that Carbon Quantum Dots effectively detected and quantified Co²⁺ ions and methylcobalamin in tap water with high sensitivity and recovery rates between 95% and 105%.

This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

This study found that 0.1% concentrations of finasteride-loaded solid lipid nanoparticles showed high entrapment efficiency and homogeneity.

This review discusses the potential of microneedles to enhance transdermal drug delivery by expanding the range of deliverable drugs, highlighting fabrication methods, material choices, and applications, but notes existing challenges with sustained delivery, cost-effectiveness, and large-scale production.

This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option.

In this study, particles similar in size to keratin cells were surprisingly found to penetrate more efficiently into hair follicles due to a possible pumping effect from moving hairs.

The researchers suggest that combining microneedle technology with nanocarriers could enhance drug delivery systems for treating central neurological diseases due to nanoparticles' ability to prolong blood circulation time and improve brain targeting.

Dissolvable microneedles are a promising, painless method for effective skin treatments.

Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

In this randomized, controlled trial, the researchers observed that sub-lingual minoxidil at doses of 1.35 mg and 4.05 mg, but not 0.45 mg, significantly increased hair fibre diameter in men with male androgenetic alopecia over 24 weeks, suggesting a dose-dependent reversal of follicle miniaturization.

This study identified new oxidative derivatives of finasteride, including a newly discovered metabolite, by using the fungus Macrophomina phaseolina.

A new microneedle system effectively delivers finasteride to treat hair loss.

This study reported the development of a pH-responsive microreactor that effectively targets infections by eradicating over 99.9% of MRSA and reprogramming the immune response to promote healing, achieving complete infection clearance and tissue regeneration in a 7-day period.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This study found that micro-CT imaging can effectively identify vascular structures in rat models of congenital hypospadias, providing anatomical insights for selecting preputial vessel flaps in surgical procedures.

In this study, micro-CT analysis revealed that severe hypospadias in finasteride-induced rats was associated with varying levels of preputial blood circulation, impacting potential surgical approaches.