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Human nails contain both skin and hair keratins, each needing different extraction methods.

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

This study identified key cells and pathways needed for the development of touch receptor patterns in mouse skin, notably that certain keratinocytes are crucial for innervation patterns, while Merkel cells and BMP signaling have distinct roles.

This review explores recent advancements in skin tissue engineering using 3D bioprinting, discussing current methods, bioink formulations, and outlining both achievements and limitations without presenting new clinical results.

In this study, researchers found that cepharanthine significantly inhibited HSV-1 replication in vitro by interfering with specific signaling pathways, arresting the cell cycle, and inducing apoptosis in infected cells, highlighting its potential as an antiviral agent.

This study found that the orphan protein Plet-1 is expressed in specific keratinocytes of mouse hair follicles and may regulate keratinocyte interactions with inert tissues by affecting migration and adhesion.

This review outlines various 3D bioprinting techniques and bioinks used for creating artificial tissues and organs, emphasizing their potential in addressing organ transplant shortages and advancing drug testing, while acknowledging existing challenges and future prospects.

The authors conclude that optimizing hair shaft production and appearance may best be achieved by integrating biological, chemical, and physical intervention strategies.

In this study, the researchers identified a variant in the CCHCR1 gene associated with an alopecia areata subtype characterized by impaired keratinization and autoimmune events.

This study found that bioengineered skin substitutes developed for 21 or 28 days effectively mimic native skin's ability to absorb UV radiation, suggesting suitability for treating severe skin defects.

This study identified Activin A and follistatin as key regulators of hair cell differentiation in the mammalian auditory sensory epithelium, with Activin A signaling influencing the timing and pattern of cell differentiation.

This study demonstrated that hyaluronan gel is a promising biomaterial for 3-D in vitro culture of mouse ovarian follicles, supporting the production of fertilizable metaphase II oocytes.

This review explores the potential of self-amplifying RNA technology for protein replacement therapy in various health disorders but reports no new experimental results, indicating challenges remain for clinical approval.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

The researchers reported that autophagy, a lysosome-dependent degradation mechanism, plays a significant role in the cellular remodeling of keratinocyte differentiation in the skin, affecting the properties of the differentiation products by altering cellular components during this process.

This study discusses the challenges in translating organoid models from laboratory settings to clinical and commercial applications, emphasizing the need for engineering approaches like environmental recapitulation and matrix engineering to bridge this gap.

This review discusses various strategies for drug repurposing in tuberculosis treatment, highlighting significant potential but reports no new clinical results.

This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.

This review explores enzyme inhibitors from gorgonians and soft corals and highlights their potential industrial and biomedical applications, but it reports no new experimental results.

This study found that the distribution of desmogleins is associated with specific types of keratinization and hair anchorage, as well as hypotrichosis.

This review highlights significant health risks associated with anabolic-androgenic steroid use in women and reports no new research results, emphasizing the need for further understanding of their effects on female physiology.

This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.

This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.

This study developed a 3D bioprinted skin model to mimic pemphigus vulgaris, providing a tool to study disease mechanisms and test targeted therapies by reproducing the architecture and pathogenic disruptions of native skin.

This study found that an enzymatic digestion method for isolating hair follicle stem cells from scalp specimens yielded 5.3 times more epithelial cells than explant cultures, while supporting comparable cell functionality, offering a promising technique for tissue engineering and regenerative medicine.

This review discusses recent advancements in bone tissue engineering, emphasizing a shift from passive to smart responsive antibacterial strategies to prevent implant-associated infections, and highlights AI's role in optimizing bone scaffold design for personalized, infection-free implants.

This review reports that oral collagen peptide supplements may improve skin elasticity, hydration, and wrinkle appearance while also supporting hair and nail health and wound healing, but emphasizes the need for longer, high-quality studies due to current research limitations and variability in findings.

This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.

This review examines recent advancements in green and emerging microextraction techniques, such as SPME and DLLME, for more sustainable hormone detection in biological samples, emphasizing environmentally friendly solvents and bioanalytical applications.

In a study using a rat model of hypertrophic scars, researchers found that gamma-irradiated human amniotic fluid improved wound healing, collagen remodelling, immune response, and scar characteristics more effectively than saline or non-irradiated amniotic fluid, indicating its potential for clinical applications in scar management.