Studysummary This study found that the distribution of desmogleins is associated with specific types of keratinization and hair anchorage, as well as hypotrichosis. Our plain-language summary of this paper — not a Tressless recommendation.
The document discussed the role of desmogleins (Dsgs), a group of calcium-dependent glycoproteins, in hair follicle differentiation and hair disorders. Dsgs were shown to be critical for cell adhesion and tissue integrity in stratified epithelia, including hair follicles (HFs). Different Dsgs, such as Dsg1, Dsg2, Dsg3, and Dsg4, were expressed in specific patterns correlating with cell differentiation states within the HF. Dsg3 was essential for anchoring telogen hair, and its absence led to hair loss in knockout mice. Dsg4 mutations were linked to hypotrichosis, highlighting its role in keratinocyte adhesion and differentiation in HFs. The study suggested that Dsgs were crucial for maintaining hair structure and function, with potential implications for understanding alopecia and other hair disorders.
50 citations
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February 2004 in “Genomics” This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.
108 citations
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July 2002 in “Molecular and cellular biology” This study found that overexpressing Dsg3 in the suprabasal epidermis of transgenic mice resulted in flaking skin and abnormal hair growth, supporting Dsg3's role in regulating epidermal differentiation.
96 citations
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December 1995 in “Journal of Investigative Dermatology” 44 citations
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August 1990 in “PubMed” This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.
198 citations
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November 1989 in “The Journal of Cell Biology” This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.
135 citations
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November 1987 in “Differentiation” This study found that cultured outer root sheath cells from human hair follicles expressed a keratin profile similar to their in vivo environment, indicating environmental influence on keratin expression.
3 citations
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January 1984 44 citations
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January 1984 in “Molecular and Cellular Biochemistry”
