September 2025 in “International Journal of Biological Macromolecules” In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.
July 2025 in “PNAS Nexus” This study integrated single-cell RNA-seq data from four previous studies to create a comprehensive human corneal cell state meta-atlas, revealing novel marker genes, rare cell states, and distinct transcription factors, and offering a tool to enhance future cornea research.
June 2025 in “Food Science & Nutrition” This study found that peimine treatment significantly improved wound healing and tissue regeneration in mice by enhancing wound closure, granulation tissue formation, and epidermal thickness, with effects linked to activation of the Notch1 signaling pathway.
March 2024 in “International journal of molecular sciences” This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.
August 2023 in “International Journal of Molecular Sciences” This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.
June 2023 in “Frontiers in Medicine” This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.
In this study, upper-bulge epidermal stem cells in mouse hair follicles were shown to play a role in forming tactile sensory units by creating an extracellular matrix that supports nerve interactions.
12 citations
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March 2022 in “Development” This review outlines the role of mechanical forces in the development of sensory organs like eyes and ears, emphasizing insights from recent animal studies and microfabricated organoid systems; it presents no new experimental results.
226 citations
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May 2004 in “Journal of Biological Chemistry” This study identified collagen XXII as a novel extracellular matrix protein specifically present at tissue junctions, where it functions as a cell adhesion ligand for skin epithelial cells and fibroblasts.
105 citations
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October 2017 in “Stem cells” This review discusses Wnt signaling pathways in skin development and stem cell regulation, highlighting potential interactions with other pathways but reports no new findings.
90 citations
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August 2004 in “Physiological Genomics” This study found that coculturing human hair follicle keratinocyte stem cells with dermal papilla cells increased expression of the hair-specific keratin 6hf gene, which requires β-catenin/lef-1 signaling for hair differentiation.
40 citations
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July 2019 in “Journal of Investigative Dermatology” In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.
40 citations
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December 2014 in “Indian Journal of Dermatology” This study found that trichoscopy can effectively differentiate scalp psoriasis from seborrheic dermatitis by identifying specific trichoscopic patterns such as hidden hairs, signet ring vessels, and comma vessels.
29 citations
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December 2004 in “Developmental biology” In this study, forced expression of the transcription factor cDermo-1 in chicken dermis led to the formation of ectopic feather buds and enhanced feather growth, demonstrating its role in initiating skin appendage development.
21 citations
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September 2003 in “Journal of Clinical Investigation” This paper reports that noggin inhibits BMP-2 and BMP-4 functions by binding and blocking their interaction with the BMP receptor, impacting multiple developmental processes without presenting new research results.
19 citations
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January 2023 in “ACS Omega” This study developed sodium alginate and epigallocatechin gallate cryogels cross-linked with ferric ions, showing that they have strong antibacterial properties and rapid hemostatic abilities, making them promising candidates for wound dressing applications.
9 citations
,
February 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of tissue mechanics and extracellular matrix in skin aging processes and highlights potential therapeutic strategies, but reports no new clinical results.
9 citations
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March 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the maintenance and morphogenesis of skin appendages rely on both the dose and duration of ectodysplasin signaling.
5 citations
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November 2024 in “Biomedicine & Pharmacotherapy” This study developed a carbohydrate chitosan-based biomaterial combined with a novel peptide to promote the chondrogenic differentiation of human adipose-derived stem cells, suggesting potential clinical applications for cartilage regeneration.
3 citations
,
November 2022 in “Frontiers in Plant Science” This study found that microwave-assisted extraction significantly increased the yield of secondary metabolites, including phenolic and flavonoid content, from Nardostachys jatamansi, enhancing its anti-Alzheimer's potential compared to conventional extraction methods.
3 citations
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October 1994 in “Journal of Dermatological Science” This study developed a novel monoclonal antibody, TYHF-1, which specifically reacts with hair keratins but not with epidermal keratins or various other tissue cells.
1 citations
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October 2025 in “Biology of Sex Differences” This study concluded that while sex-related biological factors may influence COVID-19 outcomes, they do not fully explain the differences in mortality between women and men, underscoring the need for a gendered, intersectional approach to understanding health inequities and risk factors.
1 citations
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July 2023 in “Frontiers in Immunology” This review highlights the role of chronic stress, oxidative stress, and immune processes in the development of Hashimoto’s thyroiditis and polycystic ovary syndrome, emphasizing the potential of antioxidants in their treatment based on the existing literature.
1 citations
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June 2023 in “Reproduction” This review discusses the role of microglia in mediating prenatal androgen effects on the female brain, potentially contributing to PCOS development and neuroendocrine dysfunctions, but reports no new results.
1 citations
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November 2022 in “Nutrients” This study found that piglets' rapid growth during nursery and lactation was linked to changes in microbiota composition and increased cortisol conversion, highlighting critical early life factors influencing adult microbiota establishment.
This study used whole-genome resequencing to analyze genetic diversity and selection in 17 rabbit breeds, identifying genes linked to traits like coat color and body size, which could inform breeding and conservation efforts.
52 citations
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January 2017 in “Dermatology” This article provides diagnostic and therapeutic recommendations for hidradenitis suppurativa based on a systematic literature search and expert consensus, but reports no new clinical results.
3 citations
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May 2023 in “Frontiers in Public Health” In this study, 76% of hospitalized COVID-19 patients experienced post-COVID-19 syndrome with symptoms like difficulty concentrating and fatigue lasting around 150 days, significantly impacting their quality of life through increased pain, discomfort, and anxiety.
1 citations
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March 2022 in “F1000Research” This study found that many participants in India lacked awareness and proper practices for managing COVID-19 at home, highlighting the need for educational programs.
August 2025 in “Annals of the Rheumatic Diseases” This study observed that the relationships between various criteria used to classify systemic lupus erythematosus are more consistent with chance than predictable patterns, although connections within the same organ domain are relevant.