Peimine Promotes Skin Wound Repair in Mice by Activating the Notch1 Signaling Pathway in Fibroblasts

The study demonstrates that peimine, a compound from fritillariae, significantly enhances skin wound healing in mice by activating the Notch1 signaling pathway in fibroblasts. Using 9 male mice, the research shows that peimine accelerates wound closure, with a 98.72% closure rate in the 4 mg/kg group by day 14. Peimine treatment improves tissue architecture, reduces inflammation, and promotes collagen deposition and epithelial maturation. The study highlights peimine's potential therapeutic applications but notes limitations such as incomplete understanding of its anti-inflammatory effects and dose-dependent efficacy. Future research should optimize dosing and explore Notch1's role in keratinocyte differentiation.