Diversity of Fibroblasts and Their Roles in Wound Healing

    September 2022 in “ Cold Spring Harbor Perspectives in Biology ”
    Dongsheng Jiang, Ruiji Guo, Hans‐Günther Machens, Yuval Rinkevich
    Studysummary This review discusses the heterogeneity of fibroblast subtypes in wound healing and reports no new results; the authors emphasize the potential for diverse fibroblast functions to lead to innovative therapies.
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    Research cited in this study 12

    1. Furnishing Wound Repair by the Subcutaneous Fascia International Journal of Molecular Sciences · 2021
    2. A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Esophagus Frontiers in Cell and Developmental Biology · 2021
    3. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    4. Distinct Fibroblast Lineages Give Rise to NG2+ Pericyte Populations in Mouse Skin Development and Repair Frontiers in Cell and Developmental Biology · 2021
    5. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    6. Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts Experimental Dermatology · 2020
    7. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    8. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    9. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    10. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    11. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    12. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012