A Novel Marker of Tissue Junctions, Collagen XXII
May 2004
in “
Journal of Biological Chemistry
”
Studysummary This study identified collagen XXII as a novel extracellular matrix protein specifically present at tissue junctions, where it functions as a cell adhesion ligand for skin epithelial cells and fibroblasts.
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The study identified collagen XXII as a novel marker of tissue junctions, particularly in muscle, cartilage, heart, and skin, with specific localization at sites like myotendinous junctions and around hair follicles. It was part of the FACIT protein family and acted as a cell adhesion ligand, contributing to tissue integrity and cell interactions. Collagen XXII was expressed in skeletal muscle and heart tissues, synthesized by muscle cells, and found in basement membrane zones, indicating its role in structural integrity and force transmission. The study also noted its presence in arthritic joints, suggesting implications for joint disease understanding.
