Green Approach for the Recovery of Secondary Metabolites from the Roots of Nardostachys Jatamansi Using Microwave Radiations: Process Optimization and Anti-Alzheimer Evaluation

The study investigated a green method using microwave-assisted extraction (MAE) to recover secondary metabolites from Nardostachys jatamansi roots, traditionally used for mental health benefits. The optimized MAE process, using an 80:20 hydroalcoholic solvent, was more efficient than conventional maceration, improving extraction yield and pharmacological potential. The study involved Swiss albino mice to evaluate the anti-Alzheimer's potential, showing improved cognitive function and antioxidant activity. Optimal conditions were identified as 187.04 W microwave power, 90°C temperature, and 20-minute irradiation time, maximizing extraction yield, total phenolic content, and total flavonoid content. The findings suggested that MAE could be scaled commercially to meet industrial demands for Nardostachys jatamansi extracts, enhancing the recovery of bioactive compounds for Alzheimer's disease management.