An Overview of Current Strategies and Future Prospects in Drug Repurposing in Tuberculosis

The document discusses the challenges and potential of drug repurposing in tuberculosis (TB) treatment, particularly in the face of increasing multi-drug resistance and drug-associated toxicities. Drug repurposing aims to improve drug efficacy by enhancing bioavailability and safety. The review highlights the use of whole-cell screening assays and large chemical compound libraries in identifying effective anti-TB drugs, despite challenges. It also explores target-based discovery methods, such as phenotypic screening, and the role of pharmacogenomics, drug metabolism, and bioinformatics in drug repurposing. The significance of large databases and genomics in identifying repurposable drugs is emphasized, offering promising strategies for TB management.