Recent Advances in Drug Repositioning and Rediscovery for Different Therapeutic Activities Utilizing Updated Technological Approaches

July 2025 in “ Molecular Diversity ”

Eman S. Nossier, Manal M. Anwar, Mohamed Ayman El‐Zahabi

Studysummary This review outlines drug repurposing as an efficient, low-cost strategy to identify new uses for existing drugs, highlighting various computational and experimental approaches as well as publicly available databases to aid in personalized pharmacotherapy.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Drug repurposing is an efficient, cost-effective strategy that identifies new uses for existing drugs, leveraging their known safety profiles and pharmacokinetics. This approach utilizes in silico computational and activity-based experimental methods to better understand disease mechanisms and identify repurposed drug candidates, enhancing personalized pharmacotherapy. The review discusses publicly available databases and various approaches for drug repositioning, emphasizing their characteristics and the need for future advancements in this field. This method reduces the risk of failure and increases the therapeutic value and success rate of drugs.

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